姜黄素抗胰腺癌的作用机制

俞泽元; 王科深; 任彦先; 罗长江; 曹宏泰; 焦作义

doi:10.3969/j.issn.1001-5256.2018.04.044

姜黄素抗胰腺癌的作用机制

DOI: 10.3969/j.issn.1001-5256.2018.04.044

兰州大学第二医院普外一科

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中图分类号: R735.9
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出版历程
- 出版日期: 2018-04-20

Mechanism of action of curcumin in treatment of pancreatic cancer

First Department of General Surgery, Lanzhou University Second Hospital

摘要

摘要: 姜黄素是一种从姜科植物的根茎姜黄中提取的植物多酚,具有抗炎、抗氧化、抗肿瘤、增强放化疗敏感性及保护肝肾功能等多种药理作用。它参与调控胰腺癌发展过程中的多条相关信号通路及癌基因表达,可能成为潜在的抗胰腺癌药物。针对姜黄素抑制胰腺癌细胞的增殖、诱导凋亡,以及抑制胰腺癌细胞信号传导的机制作一综述。
- 胰腺肿瘤 /
- 姜黄素 /
- 药理作用分子作用机制 /
- 综述
Abstract: Curcumin is a polyphenol extracted from the rhizome of Rhizoma Curcumae Longae with anti-inflammatory, antioxidant, and antitumor effects.It can also increase the sensitivity to chemoradiotherapy and protect hepatic and renal function.It is involved in the regulation of various signaling pathways and the expression of oncogenes and thus may become a potential anti-tumor drug for pancreatic cancer.This article reviews the mechanism of action of curcumin in inhibiting the proliferation and inducing the apoptosis of pancreatic cancer cells and inhibiting the signaling pathways involved in pancreatic cancer.
- pancreatic neoplasms /
- curcumin /
- molecular mechanisms of pharmacological action /
- review

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参考文献(49)

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