NF-κB通路在肝纤维化进展和中药抗肝纤维化机制中的作用

朱慧; 平键; 徐列明

doi:10.3969/j.issn.1001-5256.2018.04.035

NF-κB通路在肝纤维化进展和中药抗肝纤维化机制中的作用

DOI: 10.3969/j.issn.1001-5256.2018.04.035

1. 上海中医药大学附属曙光医院肝二科
2. 上海中医药大学肝病研究所
3. 肝肾疾病病证教育部重点实验室
4. 上海市中医临床重点实验室
5. 国家中医药管理局重点研究室(慢性肝病虚损)

基金项目:

上海市科委基金项目(15401902600)；

详细信息

中图分类号: R575.2
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- 被引次数: 0
出版历程
- 收稿日期: 2017-10-31
- 出版日期: 2018-04-20

Role of the nuclear factor-kappa B signaling pathway on the progress of hepatic fibrosis and the anti-fibrotic mechanism of traditional Chinese medicine

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Research funding:

摘要

摘要: 核因子-κB（NF-κB）可以通过调控基因表达,在细胞存活、生长、增殖、活化、凋亡等多种生理和病理过程中起着重要作用,尤其在肝纤维化进展中,NF-κB信号通路发挥重要调节作用。对NF-κB的结构与功能,目前有关NF-κB在参与肝纤维化进展中,对肝细胞、Kupffer细胞、肝星状细胞的调节,以及中药通过调控NF-κB通路活性发挥抗肝纤维化作用的机制作一综述。揭示了相关疾病条件下,NF-κB与多个细胞之间复杂的相互作用机制,突出中药抑制NF-κB的活性从而减轻肝纤维化这一潜在的临床意义。
- NF-κB /
- 肝硬化 /
- 中药疗法 /
- 综述
Abstract: Nuclear factor-kappa B (NF-κB) plays an important role in various physiological and pathological processes by regulating gene expression, such as cell survival, growth, proliferation, activation, and apoptosis.In particular, the NF-κB signaling pathway has an important regulatory effect on the progression of hepatic fibrosis.This article reviews the structure and function of NF-κB, the regulatory effect of NF-κB on hepatocytes, Kupffer cells, and hepatic stellate cells in the progression of hepatic fibrosis, and the anti-fibrotic mechanism of traditional Chinese medicine by regulating the activity of the NF-κB signaling pathway.We also point out the complex interaction between NF-κB and various types of cells in certain diseases and emphasize the clinical significance of traditional Chinese medicine in inhibiting the activity of NF-κB and alleviating hepatic fibrosis.
- NF-kappa B /
- liver cirrhosis /
- drug therapy (TCD) /
- review

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参考文献(38)

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