血清标志物与瞬时弹性成像技术评估肝纤维化的研究进展

许峰铭; 盛庆寿

doi:10.3969/j.issn.1001-5256.2018.03.040

血清标志物与瞬时弹性成像技术评估肝纤维化的研究进展

DOI: 10.3969/j.issn.1001-5256.2018.03.040

1. 广西中医药大学
2. 广西中医药大学附属瑞康医院肝病科

基金项目:

国家“十二五”科技重大专项(2014ZX10005001)；广西科技厅课题(GZZX15-19)；

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2018-03-20

Research advances in serum markers and transient elastography in the evaluation of liver fibrosis

Guangxi University of Chinese Medicine

Research funding:

摘要

摘要: 肝纤维化及部分早期肝硬化是可逆转的,及时准确地判断肝纤维化程度对慢性肝脏疾病的预防治疗及预后判断具有显著的临床意义。近年来,血清标志物及瞬时弹性成像技术在评估肝纤维化方面已取得较大的进展,介绍了血清学指标及其相关模型对肝纤维化的评估价值,如壳多糖酶3样蛋白1、GP模型、Forns、APRI和FIB-4指数;并简述了瞬时弹性成像检测技术在慢性肝病患者肝纤维化程度分期中的应用进展;认为二者的联合应用对肝纤维化程度的评估有较高的价值。
- 肝硬化 /
- 弹性成像技术 /
- 生物学标记 /
- 诊断 /
- 综述
Abstract: Studies have shown that liver fibrosis and some cases of early liver cirrhosis can be reversed, and thus a timely, accurate judgment of fibrosis degree has important clinical significance in prevention/treatment and prognostic evaluation of chronic liver diseases. In recent years, great achievements have been made in the application of serum markers and transient elastography for the evaluation of liver fibrosis. This article introduces the value of serological markers and related models in evaluating liver fibrosis, including CHI3 L1, GP model, Forns, APRI, and FIB-4 index, and reviews the advances in the application of transient elastography in determining fibrosis stage in patients with chronic liver diseases. It is pointed out that a combination of these two methods has a high value in evaluating fibrosis degree.
- liver cirrhosis /
- elasticity imaging techniques /
- biological markers /
- diagnosis /
- review

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参考文献(32)

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