非酒精性脂肪性肝病肠道菌群的研究进展

刘嘉琪; 周少明

doi:10.3969/j.issn.1001-5256.2017.12.045

非酒精性脂肪性肝病肠道菌群的研究进展

DOI: 10.3969/j.issn.1001-5256.2017.12.045

深圳市儿童医院

基金项目:

圳市科技创新委员会2016年基础研究项目(JCYJ20160429174706491)；

详细信息

中图分类号: R575.5
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出版历程
- 收稿日期: 2017-09-07
- 出版日期: 2017-12-20

Research advances in intestinal flora in nonalcoholic fatty liver disease

Shenzhen Children's Hospital

Research funding:

摘要

摘要: 非酒精性脂肪性肝病发病率不断升高且起病年龄渐趋低龄化,其发病机制至今尚未明确。在众多致病因素中,肠道菌群的改变与非酒精性脂肪性肝病的发病及进展密切相关。归纳了肠道菌群在非酒精性脂肪性肝病发生及发展中的作用机制,以及通过调节肠道菌群治疗非酒精性脂肪性肝病的方式。可见通过调节肠道菌群,恢复肠道微生态平衡,对延缓乃至阻止非酒精性脂肪性肝病的进展可能有重要的作用,成为预防及治疗该病的新方法。
- 非酒精性脂肪性肝病 /
- 肠杆菌科 /
- 综述
Abstract: Nonalcoholic fatty liver disease ( NAFLD) is a common chronic liver disease in our country, and its incidence rate is gradually increasing and the age of onset is becoming younger. The pathogenesis of NAFLD remains unclear. Among a variety of pathogenic factors, the change in intestinal flora is closely associated with the development and progression of NAFLD. This article summarizes the mechanism of action of intestinal flora in the development and progression of NAFLD and the treatment of NAFLD by regulating intestinal flora. It is pointed out that regulation of intestinal flora and restoration of intestinal microecological balance may play an important role in delaying or inhibiting the progression of NAFLD and may become a new method for the prevention and treatment of this disease.
- nonalcoholic fatty liver disease /
- enterobacteriaceae /
- review

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参考文献(24)

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