非酒精性脂肪性肝病相关肝纤维化及其组织学量化分析

汪艳; 侯金林

doi:10.3969/j.issn.1001-5256.2017.12.008

非酒精性脂肪性肝病相关肝纤维化及其组织学量化分析

DOI: 10.3969/j.issn.1001-5256.2017.12.008

汪艳,
侯金林

1. 器官衰竭防治国家重点实验室广东省肝纤维化工程技术研究中心南方医科大学肝病研究所
2. 南方医科大学南方医院感染内科暨肝病中心

基金项目:

国家自然科学基金(81670522)；广州市科技计划项目(201607020019)；

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2017-12-20

Hepatic fibrosis in nonalcoholic fatty liver disease and its quantitative assessment

Research funding:

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)正逐渐成为慢性肝病肝纤维化发生的首要原因。组织学肝纤维化可能是目前对NAFLD预后进行判断的最重要独立影响因素。NAFLD相关肝纤维化在肝病进展中具有与其"代谢性"病生机制紧密相关的特征:其发生发展与肥胖、代谢综合征相关危险因素、年长等主要因素显著相关;其组织学分布、变化特征以及与其他组织学特征的关联性也不同于其他主要肝病。在已有组织学评价标准的基础上,准确量化分析NAFLD相关肝纤维化对于疾病分层、疗效观察以及新型诊疗工具研发可能具有研究和应用价值。
- 非酒精性脂肪性肝病 /
- 肝硬化 /
- 组织学
Abstract: Nonalcoholic fatty liver disease ( NAFLD) is becoming a primary etiology underlying the chronic liver injury-related fibrogenesis among general population. Histologic fibrosis has been demonstrated as the most important independent predictor for the major outcomes of NAFLD patients. NAFLD-related fibrosis has distinct characteristics through the disease course, which is largely attributed to its " metabolic" pathophysiology: The progression of fibrosis is correlated to the factors including obesity, metabolic syndrome components, aging, etc.;and the patterns of histologic distribution and evolution as well as the association with the other histological features are remarkably different from those of the other chronic liver diseases. Based on the criteria of current standard histology, accurate quantitative assessment of NAFLD fibrosis could be relevant in terms of research and utilization to stratifying the disease risk, monitoring the therapeutic response, as well as to facilitating the development of new diagnostic tools.
- nonalcoholic fatty liver disease /
- liver cirrhosis /
- histology

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参考文献(58)

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