对熊去氧胆酸应答不佳的原发性胆汁性胆管炎治疗策略

施漪雯; 尤红

doi:10.3969/j.issn.1001-5256.2017.11.010

对熊去氧胆酸应答不佳的原发性胆汁性胆管炎治疗策略

DOI: 10.3969/j.issn.1001-5256.2017.11.010

施漪雯,
尤红

首都医科大学附属北京友谊医院肝病研究中心肝硬化转化医学北京市重点实验室国家消化系统疾病临床医学研究中心

详细信息

中图分类号: R575.22
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出版历程
- 收稿日期: 2017-09-03
- 出版日期: 2017-11-20

Therapeutic strategies for patients with primary biliary cholangitis and suboptimal response to ursodeoxycholic acid

Shi YiWen,
You Hong

Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center for Digestive Diseases

摘要

摘要: 原发性胆汁性胆管炎(PBC)的治疗近年来主要应用熊去氧胆酸,而增长的患者人数、应答不佳和治疗不耐受的出现对治疗方案提出了挑战,新药奥贝胆酸的获批为PBC患者带来了希望,联合使用贝特类药物也具有前景,更多的试验正在进行之中。新型药物如单克隆抗体、成纤维细胞生长因子19、钠依赖性胆汁酸转运蛋白抑制剂等虽然疗效数据有限,但为PBC治疗提供了新的方向。通过个性化随访以及分层治疗,PBC患者的管理将进入新的阶段。
- 胆管炎,胆汁性 /
- 熊脱氧胆酸 /
- 鹅脱氧胆酸 /
- 氯贝酸 /
- 糖皮质激素类 /
- 抗体,单克隆
Abstract: In recent years, ursodeoxycholic acid is commonly used for the treatment of primary biliary cholangitis (PBC) ;however, the growing number of PBC patients and the occurrence of suboptimal response and treatment intolerance pose a great challenge to treatment regimens.The approval of the new drug obeticholic acid brings hope to PBC patients, and a combination of fibrates also has a promising future.More studies are in progress.Although new drugs, such as monoclonal antibody, fibroblast growth factor 19, and sodium-dependent bile acid transporter inhibitor, have limited efficacy data, they provide new directions for the treatment of PBC.With the help of individualized follow-up and stratified therapy, the management of PBC patients will enter a new stage.
- cholangitis, biliary /
- ursodeoxycholic acid /
- chenodeoxycholic acid /
- clofibric acid /
- glucocrticoids /
- antibodies, monoclonal

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参考文献(21)

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