外泌体与肝脏疾病的关系

吴俊成; 徐铭益

doi:10.3969/j.issn.1001-5256.2017.09.042

外泌体与肝脏疾病的关系

DOI: 10.3969/j.issn.1001-5256.2017.09.042

上海交通大学附属第一人民医院消化科

基金项目:

国家自然科学基金(81570547)；国家科技部“十二五”重大专项(2012ZX10002007-001-040,2013ZX10002004-002-003)；院优秀青年人才计划(061405)；

详细信息

中图分类号: R575
计量
- 文章访问数: 1961
- HTML全文浏览量: 35
- PDF下载量: 418
- 被引次数: 0
出版历程
- 收稿日期: 2017-02-04
- 出版日期: 2017-09-20

Research advances in the association between exosomes and liver diseases

Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University

Research funding:

摘要

摘要: 外泌体是细胞经过"內吞-融合-外排"等过程形成的直径在30100 nm的胞外囊泡。多种细胞均可以释放外泌体,这些外泌体可携带脂质、蛋白质和核酸等重要的生物分子,参与细胞间的信号转导及物质交换,调节体内多个系统的生理病理过程,其在多种肝脏疾病中发挥至关重要的作用,如肝癌、病毒性肝炎、肝纤维化、酒精性及非酒精性脂肪肝等。对外泌体在肝脏疾病中的研究进展作一综述。
- 外泌体 /
- 肝疾病 /
- 综述
Abstract: Exosomes are extracellular vesicles with a diameter of 30-100 nm formed during the processes of“endocytosis-fusion-exocytosis”. Exosomes can be released by various types of cells and may carry important biological molecules, such as lipids, proteins, and nucleic acids. They are also involved in signal transduction and exchange of substances between cells and can regulate the physiological and pathological processes in various systems. They also play an important role in liver diseases, including liver cancer, viral hepatitis, liver fibrosis, and alcoholic and non-alcoholic fatty liver disease. This article reviews the research advances in exosomes in liver diseases.
- exosomes /
- liver diseases /
- review

HTML全文

参考文献(46)

[1] JOHNSTONE RM, ADAM M, HAMMOND JR, et al.Vesicle formation during reticulocyte maturation.Association of plasma membrane activities with released vesicles (exosomes) [J].J Biol Chem, 1987, 262 (19) :9412-9420.

[2]NATASHA G, GUNDOGAN B, TAN A, et al.Exosomes as immunotheranostic nanoparticles[J].Clin Ther, 2014, 36 (6) :820-829.

[3] URBANELLI L, MAGINI A, BURATTA S, et al.Signaling pathways in exosomes biogenesis, secretion and fate[J].Genes (Basel) , 2013, 4 (2) :152-170.

[4] CABY MP, LANKAR D, VINCENDEAU-SCHERRER C, et al.Exosomal-like vesicles are present in human blood plasma[J].Int Immunol, 2005, 17 (7) :879-887.

[5] YEZ-MM, SILJANDER PR, ANDREU Z, et al.Biological properties of extracellular vesicles and their physiological functions[J].J Extracell Vesicles, 2015, 4:27066.

[6]MASYUK AI, MASYUK TV, LARUSSO NF.Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases[J].JHepatol, 2013, 59 (3) :621-625.

[7]NOJIMA H, FREEMAN CM, SCHUSTER RM, et al.Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate[J].J Hepatol, 2016, 64 (1) :60-68.

[8]CHEN L, CHEN R, KEMPER S, et al.Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression:role of exosomes in horizontal transfer of Twist1[J].Am J Physiol Gastrointest Liver Physiol, 2015, 309 (6) :g491-g499.

[9] SAHA B, MOMEN-HERAVI F, KODYS K, et al.MicroRNAcargo of extracellular vesicles from alcoholexposed monocytes signals naive monocytes to differentiate into M2 macrophages[J].J Biol Chem, 2016, 291 (1) :149-159.

[10]CONDE-VANCELLS J, GONZALEZ E, LU SC, et al.Overview of extracellular microvesicles in drug metabolism[J].Expert Opin Drug Metab Toxicol, 2010, 6 (5) :543-554.

[11] CONIGLIARO A, COSTA V, LO DICO A, et al.CD90+liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA[J].Mol Cancer, 2015, 14:155.

[12] HUANG A, DONG J, LI S, et al.Exosomal transfer of vasorin expressed in hepatocellular carcinoma cells promotes migration of human umbilical vein endothelial cells[J].Int J Biol Sci, 2015, 11 (8) :961-969.

[13] HE M, QIN H, POON TC, et al.Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs[J].Carcinogenesis, 2015, 36 (9) :1008-1018.

[14] QU Z, WU J, WU J, et al.Exosomes derived from HCC cells induce sorafenib resistance in hepatocellular carcinoma both in vivo and in vitro[J].J Exp Clin Cancer Res, 2016, 35 (1) :159.

[15] TAKAHASHI K, YAN I K, HAGA H, et al.Modulation of hypoxia-signaling pathways by extracellular linc-RoR[J].J Cell Sci, 2014, 127 (Pt 7) :1585-1594.

[16] TAKAHASHI K, YAN IK, WOOD J, et al.Involvement of extracellular vesicle long noncoding RNA (linc-VLDLR) in tumor cell responses to chemotherapy[J].Mol Cancer Res, 2014, 12 (10) :1377-1387.

[17]KOUWAKI T, FUKUSHIMA Y, DAITO T, et al.Extracellular vesicles including exosomes regulate innate immune responses to hepatitis B virus infection[J].Front Immunol, 2016, 7:355.

[18] YANG Y, HAN Q, HOU Z, et al.Exosomes mediate hepatitis Bvirus (HBV) transmission and NK-cell dysfunction[J].Cell Mol Immunol, 2016, 13:1-11.

[19]LIU Z, ZHANG X, YU Q, et al.Exosome-associated hepatitis Cvirus in cell cultures and patient plasma[J].Biochem Biophys Res Commun, 2014, 455 (3-4) :218-222.

[20] BUKONG TN, MOMEN-HERAVI F, KODYS K, et al.Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90[J].PLo S Pathog, 2014, 10 (10) :e1004424.

[21] HARWOOD NM, GOLDEN-MASON L, CHENG L, et al.HCV-infected cells and differentiation increase monocyte immunoregulatory galectin-9 production[J].J Leukoc Biol, 2016, 99 (3) :495-503.

[22]GIUGLIANO S, KRISS M, GOLDEN-MASON L, et al.Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication[J].Gastroenterology, 2015, 148 (2) :392-402.

[23]VERMA VK, LI H, WANG R, et al.Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles[J].J Hepatol, 2016, 64 (3) :651-660.

[24]IBRAHIM SH, HIRSOVA P, TOMITA K, et al.Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes[J].Hepatology, 2016, 63 (3) :731-744.

[25]HIRSOVA P, IBRAHIM SH, KRISHNAN A, et al.Lipid-induced signaling causes release of inflammatory extracellular vesicles from hepatocytes[J].Gastroenterology, 2016, 150 (4) :956-967.

[26] KAKAZU E, MAUER AS, YIN M, et al.Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner[J].J Lipid Res, 2016, 57 (2) :233-245.

[27] SEO W, EUN HS, KIM SY, et al.Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17production byγδT cells in liver fibrosis[J].Hepatology, 2016, 64 (2) :616-631.

[28]CHARRIER A, CHEN R, CHEN L, et al.Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver[J].Surgery, 2014, 156 (3) :548-555.

[29]CHEN L, CHARRIER A, ZHOU Y, et al.Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells[J].Hepatology, 2014, 59 (3) :1118-1129.

[30] CHEN L, BRIGSTOCK DR.Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC-derived exosomes[J].FEBS Lett, 2016, 590 (23) :4263-4274.

[31] WANG R, DING Q, YAQOOB U, et al.Exosome adherence and internalization by hepatic stellate cells triggers sphingosine 1-phosphate-dependent migration[J].J Biol Chem, 2015, 290 (52) :30684-30696.

[32]WANG X, DING X, NAN L, et al.Investigation of the roles of exosomes in colorectal cancer liver metastasis[J].Oncol Rep, 2015, 33 (5) :2445-2453.

[33] COSTA-SILVA B, AIELLO NM, OCEAN AJ, et al.Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver[J].Nat Cell Biol, 2015, 17 (6) :816-826.

[34] HOSHINO A, COSTA-SILVA B, SHEN TL, et al.Tumour exosome integrins determine organotropic metastasis[J].Nature, 2015, 527 (7578) :329-335.

[35] SOHN W, KIM J, KANG SH, et al.Serum exosomal microRNAs as novel biomarkers for hepatocellular carcinoma[J].Exp Mol Med, 2015, 47:e184.

[36] FORNARI F, FERRACIN M, TRERD, et al.Circulating microRNAs, miR-939, miR-595, miR-519d and miR-494, identify cirrhotic patients with HCC[J].PLo S One, 2015, 10 (10) :e0141448.

[37] SUGIMACHI K, MATSUMURA T, HIRATA H, et al.Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation[J].Br J Cancer, 2015, 112 (3) :532-538.

[38] MOMEN-HERAVI F, SAHA B, KODYS K, et al.Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis[J].J Transl Med, 2015, 13:261.

[39] POVERO D, EGUCHI A, LI H, et al.Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease[J].PLo S One, 2014, 9 (12) :e113651.

[40] RAO Q, ZUO B, LU Z, et al.Tumor-derived exosomes elicit tumor suppression in murine hepatocellular carcinoma models and humans in vitro[J].Hepatology, 2016, 64 (2) :456-472.

[41]KO SF, YIP HK, ZHEN YY, et al.Adipose-derived mesenchymal stem cell exosomes suppress hepatocellular carcinoma growth in a rat model:apparent diffusion coefficient, natural killer T-cell responses, and histopathological features[J].Stem Cells Int, 2015, 2015:853506.

[42]WEI JX, LV LH, WAN YL, et al.Vps4A functions as a tumor suppressor by regulating the secretion and uptake of exosomal microRNAs in human hepatoma cells[J].Hepatology, 2015, 61 (4) :1284-1294.

[43] LI T, YAN Y, WANG B, et al.Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis[J].Stem Cells Dev, 2013, 22 (6) :845-854.

[44] HYUN J, WANG S, KIM J, et al.MicroRNA125b-mediated Hedgehog signaling influences liver regeneration by chorionic plate-derived mesenchymal stem cells[J].Sci Rep, 2015, 5:14135.

[45] NONG K, WANG W, NIU X, et al.Hepatoprotective effect of exosomes from human-induced pluripotent stem cell-derived mesenchymal stromal cells against hepatic ischemia-reperfusion injury in rats[J].Cytotherapy, 2016, 18 (12) :1548-1559.

[46] TAN CY, LAI RC, WONG W, et al.Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models[J].Stem Cell Res Ther, 2014, 5 (3) :76.

施引文献

资源附件(0)

访问统计