神经酰胺在非酒精性脂肪性肝病发生发展中的作用

韩海静; 齐雪; 牛春燕

doi:10.3969/j.issn.1001-5256.2017.08.038

神经酰胺在非酒精性脂肪性肝病发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2017.08.038

1. 西安医学院
2. 西安医学院第一附属医院

基金项目:

基金项目:陕西省优势学科(陕教位[2014]3号文件)；

详细信息

中图分类号: R575.5
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- 被引次数: 0
出版历程
- 收稿日期: 2017-01-22
- 出版日期: 2017-08-20

Role of ceramide in development and progression of nonalcoholic fatty liver disease

Xi'an Medical University

Research funding:

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)是除外酒精和其他明确的肝损害因素所致的,以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合征。"二次打击"学说可以部分解释NAFLD的发病机制。神经酰胺是NAFLD发生发展中关键的分子信使,而且其作为一种鞘脂与"二次打击学说"密切相关。对神经酰胺在NAFLD中的作用进行了综述。
- 脂肪肝 /
- 神经酰胺类 /
- 综述
Abstract: Nonalcoholic fatty liver disease ( NAFLD) is a clinicopathological syndrome caused by liver damage factors except alcohol and has the major feature of diffuse macrovesicular hepatocyte steatosis. The " two-hit " hypothesis can partly explain the pathogenesis of NAFLD. Recent studies have found that ceramide is a key molecular messenger involved in the development and progression of NAFLD, and as a sphingolipid, it is closely associated with the " two-hit" hypothesis. This article reviews the role of ceramide in NAFLD.
- fatty liver /
- ceramides /
- review

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参考文献(46)

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