非酒精性脂肪性肝病发病机制新认识

辛晟梁; 徐可树

doi:10.3969/j.issn.1001-5256.2017.08.037

非酒精性脂肪性肝病发病机制新认识

DOI: 10.3969/j.issn.1001-5256.2017.08.037

华中科技大学同济医学院附属协和医院消化内科

详细信息

中图分类号: R575.5
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出版历程
- 收稿日期: 2017-02-22
- 出版日期: 2017-08-20

A new understanding of the pathogenesis of nonalcoholic fatty liver disease

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

摘要

摘要: 近年来我国非酒精性脂肪性肝病(NAFLD)发病率越来越高,达到11%~15%。目前认为"多次打击"学说是NAFLD的主要发病机制,但确切机制尚未明确。从肝脏高表达蛋白质癌胚抗原相关细胞黏附分子1、维生素D受体轴、精神心理因素等较为新颖的角度阐述了其与NAFLD发生发展的关系,以期为今后研究NAFLD发病机制提供新的方向。
- 脂肪肝 /
- 细胞黏附分子 /
- 维生素D /
- 精神障碍 /
- 综述
Abstract: The incidence rate of nonalcoholic fatty liver disease ( NAFLD) has been increasing in China in recent years and has reached11%-15%. At present, the " multiple-hit" hypothesis is considered the main pathogenesis of NAFLD, yet the specific pathogenesis remains unknown. This article elaborates on the roles of carcinoembryonic antigen-related cell adhesion molecule 1 highly expressed in the liver, vitamin D/vitamin D receptor axis, and psychological factors in the development and progression of NAFLD, in order to provide new directions for the research on the pathogenesis of NAFLD in future.
- fatty liver /
- cell adhesion molecules /
- vitamin D /
- mental disorders /
- review

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参考文献(20)

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