成体肝祖细胞的研究进展

李飞; 马振增; 陆伦根

doi:10.3969/j.issn.1001-5256.2017.05.043

成体肝祖细胞的研究进展

DOI: 10.3969/j.issn.1001-5256.2017.05.043

上海交通大学附属上海市第一人民医院消化科

基金项目:

国家自然科学基金资助项目(81470858)； 2015年上海市领军人才计划(056)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2017-05-20

Research advances in adult hepatic progenitor cells

Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University

Research funding:

摘要

摘要:
肝脏具有极强的再生能力,在遭受急性损伤时,由成熟肝细胞增殖完成肝再生。但在肝脏遭受慢性损伤时,成熟肝细胞增殖能力受损或耗竭,肝祖细胞活化、增殖、分化,参与肝再生。介绍了肝祖细胞的特征及来源,在肝损伤后组织修复和肝癌发生中的作用,以及用于细胞移植治疗肝脏疾病的潜能和面临的问题。认为对于肝祖细胞的生物学特性及其在肝损伤和肝癌中的作用和发病机制的认识有利于肝病的治疗。
- 肝祖细胞 /
- 肝再生 /
- 癌,肝细胞 /
- 干细胞移植 /
- 综述
Abstract:
The liver has a strong regenerative capacity, and in case of acute injury, the proliferation of mature hepatocytes helps to complete liver regeneration.However, in case of chronic injury, the proliferative capacity of mature hepatocytes is damaged or exhausted, and the activation, proliferation, and differentiation of hepatic progenitor cells are involved in liver regeneration.This article summarizes the characteristics and origins of hepatic progenitor cells, their role in tissue repair after liver injury and development of liver cancer, and potentials and problems of cell transplantation in the treatment of liver diseases.It is pointed out that an understanding of the biological characteristics of hepatic progenitor cells, their role in liver injury and liver cancer, and related pathogenesis helps with the treatment of liver diseases.
- hepatic progenitor cells /
- liver regeneration /
- carcinoma, hepatocellular /
- stem cell transplantation /
- review

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参考文献(31)

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