肝细胞癌癌前异型增生结节的研究现状

焦俊喆; 李京涛; 闫曙光; 魏海梁; 鞠迪; 宋艺君; 常占杰

doi:10.3969/j.issn.1001-5256.2017.05.039

肝细胞癌癌前异型增生结节的研究现状

DOI: 10.3969/j.issn.1001-5256.2017.05.039

1. 陕西中医药大学
2. 陕西中医药大学附属医院

基金项目:

国家自然科学基金(81603612)；陕西省科技厅课题(2012SF2-11,2014K11-02-04-06,2016SF-234)；陕西省中医药管理局课题(15-JC009)；北京医学奖励基金会课题(YJHYXKYJJ-276)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2017-05-20

Current research status of precancerous dysplastic nodules in hepatocellular carcinoma

Shaanxi University of Chinese Medicine, Xianyang

Research funding:

摘要

摘要:
异型增生结节(DN)是肝细胞癌(HCC)癌前病变向HCC演变的重要阶段,具有极高的癌变风险。依据细胞异型性的不同,DN可分为低度异型增生结节(LGDN)和高度异型增生结节(HGDN),总结了LGDN与HGDN的病理特点、影像学特征及生物标志物,简述了DN恶变为HCC的风险大小,指出应当提高临床医师对于HCC癌前病变DN的认识,通过对DN的筛查发现恶变风险高的结节并进行干预,以防止HCC的发生。
- 癌,肝细胞 /
- 异型增生结节 /
- 病理状态,体征和症状 /
- 生物学标记 /
- 综述
Abstract:
Dysplastic nodule (DN) is an important stage for precancerous hepatocellular carcinoma (HCC) lesions progressing to HCC and has a very high risk of canceration.According to the difference in atypia, DN is classified into low-grade DN (LGDN) and high-grade DN (HGDN) .This article summarizes the pathological features, radiological features, and biomarkers of LGDN and HGDN, briefly describes the risk of the canceration of DN into HCC, and points out that it is necessary to enhance the knowledge of DN, the precancerous HCC lesions, in clinical physicians.DN screening to identify nodules with a high risk of canceration and related intervention help to prevent the development of HCC.
- carcinoma, hepatocellular /
- dysplastic nodule /
- pathological conditions, signs and symptoms /
- biological markers /
- review

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