慢性HBV感染免疫耐受研究进展

吴凤萍; 党双锁

doi:10.3969/j.issn.1001-5256.2017.05.034

慢性HBV感染免疫耐受研究进展

DOI: 10.3969/j.issn.1001-5256.2017.05.034

西安交通大学第二附属医院感染科

基金项目:

国家自然科学基金资助项目(81170393)；

详细信息

中图分类号: R512.62
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出版历程
- 出版日期: 2017-05-20

Research advances in immune tolerance in chronic hepatitis B virus infection

Department of Infectious Diseases, The Second Affiliated Hospital of Xi′an Jiaotong University

Research funding:

摘要

摘要:
免疫耐受是T及B淋巴细胞对抗原的特异不应答或负应答表现。按形成时期的不同,免疫耐受可分为中枢耐受和外周耐受。HBV感染后机体对HBV免疫耐受是慢性HBV感染的主要原因。简要介绍了HBe Ag、树突状细胞的功能缺陷、细胞毒性T淋巴细胞低应答、辅助性T淋巴细胞及细胞因子、HBV基因型及基因组的变异、宿主基因多态性在慢性HBV感染免疫耐受形成中的作用及相关研究进展。
- 肝炎病毒,乙型 /
- 嗜肝DNA病毒科感染 /
- 免疫耐受 /
- 综述
Abstract:
Immune tolerance refers to the specific non-response or negative response of T and B lymphocytes to antigens.According to the period of formation, immune tolerance can be classified into central tolerance and peripheral tolerance.Immune tolerance to hepatitis B virus (HBV) after HBV infection is considered a major cause of chronic HBV infection.This article briefly reviews the roles of HBe Ag, functional defects of dendritic cells, low response of cytotoxic T lymphocytes, T helper cells and cytokines, variations of HBV genotype and genome, and host gene polymorphisms in the development of immune tolerance in chronic HBV infection, as well as related research advances.
- hepatitis B virus /
- hepadnaviridae infections /
- immune tolerance /
- review

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参考文献(33)

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