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药物性肝损伤临床分型特点及其与肝组织学改变的关系

徐曾丽 高敏 郭春霞 邢敏丹 李嘉

引用本文:
Citation:

药物性肝损伤临床分型特点及其与肝组织学改变的关系

DOI: 10.3969/j.issn.1001-5256.2017.05.027
基金项目: 

天津市卫生计生委科技基金项目(2015KZ011); 

详细信息
  • 中图分类号: R575

Clinical features of different types of drug-induced liver injury and their association with liver histological changes

Research funding: 

 

  • 摘要:

    目的分析不同临床分型药物性肝损伤(DILI)患者的临床特征,并比较临床分型与病理损伤分型的关系。方法收集2014年1月-2016年1月天津市第二人民医院收治的289例DILI患者,依据生化指标计算"R值"将DILI临床分型分为:肝细胞损伤型、胆汁淤积型和混合型,分别统计其用药情况、生化指标,并对行肝脏病理检查患者的肝组织学改变进行分析,比较其病理损伤类型与临床分型的一致性。非正态分布的计量资料多组间比较采用非参数Kruskal-Wallis H检验;正态分布的计量资料多组间比较采用单因素方差分析。计数资料组间比较采用χ2检验。结果依据R值将289例DILI患者分为:肝细胞损伤型181例(62.63%)、胆汁淤积型55例(19.03%)以及混合型53例(18.34%)。其中致肝损伤的药物以中(草)药所占比例最大(48.79%)。共152例患者行肝脏病理检查,依据组织学改变情况分为:肝细胞损伤型43例(28.29%),胆汁淤积型8例(5.26%),混合型101例(66.45%);该152例患者依据R值的临床分型为:肝细胞损伤型95例(62.50%),胆汁淤积型29例(...

     

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