基于文献分析我国药物性肝损伤诊断标准的使用情况

张冬; 张涛; 伍玉南; 孙克伟

doi:10.3969/j.issn.1001-5256.2017.05.026

基于文献分析我国药物性肝损伤诊断标准的使用情况

DOI: 10.3969/j.issn.1001-5256.2017.05.026

1. 湖南中医药大学研究生院
2. 湖南中医药大学第一附属医院肝病研究所

基金项目:

国家中医临床研究基地业务建设第二批科研专项课题(2015F01)；

详细信息

中图分类号: R575;G353.1
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出版历程
- 出版日期: 2017-05-20

A systematic analysis of the application of diagnostic criteria for drug-induced liver injury in China based on the literature

Graduate School, Hunan University of Chinese Medicine

Research funding:

摘要

摘要:
目的分析我国药物性肝损伤诊断标准的使用情况。方法用中国期刊全文专题数据库、维普中文科技期刊数据库、万方数据进行检索,检索年限为1990-2015年,并记录文献中的诊断标准,分析目前中国药物性肝损伤诊断标准的使用现状。结果纳入文献609篇,其中包括病例系列410篇,病例报告199篇。我国使用的诊断标准达15种,仅13.4%的文献采用的是国际推荐的因果关系评估法。46%的文献报道的病例仅根据用药史结合临床症状、排除常见肝损伤病因做出诊断。结论我国药物性肝损伤诊断标准多,诊断的主观性强,诊断缺乏严谨性。
- 药物性肝损伤 /
- 诊断 /
- 参考标准
Abstract:
Objective To investigate the application of diagnostic criteria for drug-induced liver injury in China.Methods CNKI, VIP, and Wanfang Data were searched for articles published from 1990 to 2015, and the diagnostic criteria in the articles were recorded to investigate the current application of diagnostic criteria for drug-induced liver injury.Results A total of 609 articles were included, with 410 articles of case studies and 199 case reports.A total of 15 types of diagnostic criteria were used in China, and only 13.4% of these articles used the causality assessment method recommended by the international community.In 46% of the cases reported in the articles, a diagnosis was made based on clinical symptoms and exclusion of common causes of liver injury.Conclusion There are many diagnostic criteria for drug-induced liver injury in China, and the diagnosis is subjective and lacks rigor.
- drug induced liver injury /
- diagnosis /
- reference standards

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参考文献(35)

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