Long-term relief in patients with hepatocellular carcinoma treated with donafenib tosylate: a report of two cases
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摘要: <正>原发性肝癌在肿瘤相关性死亡中排第3位[1],由于起病隐匿、进展迅速,临床上仅有不足30%的患者就诊时可获得手术治疗的机会,因此,非手术疗法是中晚期肝癌的主要治疗方式[2]。目前以索拉非尼为代表的激酶抑制剂成为第一个治疗原发性肝癌的靶向治疗药物[3-5]。甲苯磺酸多纳非尼将索拉非尼分子上的一个甲基取代为三氘代甲基后形成全新结构的新药,与索拉非尼具有相似的分子结构和作用机制。笔者在多纳非尼的ⅠB期临床试验中,发现2例
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Key words:
- liver neoplasms /
- targeted therapy /
- case reports
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