探索HBV相关肝衰竭诊治的新思路

杨方集; 彭亮; 高志良

doi:10.3969/j.issn.1001-5256.2017.03.041

探索HBV相关肝衰竭诊治的新思路

DOI: 10.3969/j.issn.1001-5256.2017.03.041

中山大学附属第三医院感染性疾病科

详细信息

中图分类号: R512.62;R575.3
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出版历程
- 收稿日期: 2016-10-12
- 出版日期: 2017-03-20

New strategies for diagnosis and treatment of hepatitis B virus-related liver failure

Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University

摘要

摘要: HBV相关肝衰竭患者的病死率极高,且其发病过程非常复杂,机制并未完全明了,临床诊治非常棘手。除了肝移植,肝衰竭的内科治疗尚缺乏特效药物和手段。总结了HBV相关肝衰竭诊断与治疗方面的经验和研究成果,在发病机制方面,探索宿主遗传背景和慢性乙型肝炎是否发展加重的关系,阐述肝衰竭发生过程中的"三重打击"现象及"四个时相"概念;在治疗方面,重点探讨抗病毒、抗感染、糖皮质激素和干细胞移植等在临床上的应用情况;在病情评估方面,建立一套更适合乙型肝炎肝衰竭预后评估的系统。
- 肝功能衰竭 /
- 肝炎病毒,乙型 /
- 诊断 /
- 治疗 /
- 综述
Abstract: Hepatitis B virus (HBV) -related liver failure has an extremely high mortality rate and a complex pathogenesis, and since related mechanisms are not fully understood, it has been very difficult to diagnose and treat this disease in clinical practice.Apart from liver transplantation, there is still a lack of specific and effective drugs and therapies for the medical treatment of HBV-related liver failure.This article summarizes our experience and research achievements in the diagnosis and treatment of HBV-related liver failure, explores the association between host's genetic background and development and aggravation of chronic hepatitis B, and elaborates on the phenomenon of“three attacks”and the concept of“four time phases”.In the aspect of treatment, this article focuses on the clinical application of antiviral therapy, anti-infective therapy, glucocorticoids, and stem cell transplantation;for the evaluation of patients' condition, this article establishes a suitable system for evaluating the prognosis of HBV-related liver failure.
- liver failure /
- hepatitis B virus /
- diagnosis /
- therapy /
- review

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参考文献(39)

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