自然杀伤细胞对肝星状细胞的调控及其在肝纤维化中的作用

李天阳; 涂正坤; 苏立山

doi:10.3969/j.issn.1001-5256.2017.03.036

自然杀伤细胞对肝星状细胞的调控及其在肝纤维化中的作用

DOI: 10.3969/j.issn.1001-5256.2017.03.036

吉林大学第一医院转化医学研究院

基金项目:

国家自然科学基金(81373143,81571535)；

详细信息

中图分类号: R575.2
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出版历程
- 收稿日期: 2016-12-15
- 出版日期: 2017-03-20

Regulatory effect of natural killer cells on hepatic stellate cells and their role in liver fibrosis

Research Institute of Translational Medicine, The First Hospital of Jilin University

Research funding:

摘要

摘要: 肝星状细胞(HSC)的激活与肝纤维化进展有至关重要的联系。作为固有免疫的重要组分,自然杀伤细胞(NK细胞)在肝内的富集程度更高,在机体防御病毒感染和肿瘤中发挥关键作用,而且其抗肝纤维化的功能也得到证实。NK细胞可以通过直接杀伤早期激活或衰老的HSC,或通过分泌IFNγ抑制肝纤维化。总结了最近几年的相关研究进展,以NK细胞和HSC的功能与表型为基础,介绍了NK细胞调控HSC的分子免疫学机制及其潜在的抗肝纤维化作用。
- 肝硬化 /
- 杀伤细胞,天然 /
- 肝星状细胞 /
- 综述
Abstract: Hepatic stellate cell (HSC) activation is closely associated with the progression of liver fibrosis.As an important component of the innate immune system, natural killer (NK) cells are enriched in the liver and play a key role in host defense against viral infection and tumor, and their anti-fibrotic effect has also been confirmed.NK cells can reduce liver fibrosis by killing early-activated or senescent HSCs or secreting interferon-γ.This article summarizes related research advances in recent years, and introduces the molecular immunological mechanism of NK cells in regulating HSCs and their potential anti-fibrotic effect based on the function and phenotype of NK cells and HSCs.
- liver cirrhosis /
- killer cells /
- natural /
- hepatic stellate cells

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参考文献(60)

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