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老年药物性肝损伤患者临床特征分析

姬琛华 张竹青 王晓媛 卢书明

引用本文:
Citation:

老年药物性肝损伤患者临床特征分析

DOI: 10.3969/j.issn.1001-5256.2017.03.021
基金项目: 

辽宁省自然科学基金资助项目(2015020324); 大连市卫生局课题; 

详细信息
  • 中图分类号: R575

Clinical features of elderly patients with drug-induced liver injury

Research funding: 

 

  • 摘要:

    目的分析老年药物性肝损伤(DILI)患者的临床特征。方法回顾性分析2010年1月-2015年12月于大连市中心医院及大连医科大学附属第一医院住院的老年和中青年DILI患者的临床资料,包括性别、年龄、基础疾病、导致肝损伤药物的种类、主要临床表现、肝功能指标(血清ALT、AST、ALP、GGT、Alb、TBil、DBil)、临床分型、治疗及转归等。计数资料2组间比较采用χ2检验,计量资料2组间比较采用Kolmogorov-Smirnov Z检验。结果 350例DILI患者中老年患者98例。老年组患者基础疾病前三位分别为心脑血管疾病(31.6%)、骨关节病(26.5%)、恶性肿瘤(18.4%),其所占比例均明显高于中青年组(5.6%、6.3%、4.8%),差异均有统计学意义(χ2值分别为42.825、27.214、16.667,P值均<0.001),老年组患者感染性疾病所占比例明显低于中青年组(5.1%vs 29.4%,χ2=23.768,P<0.001);引起肝损伤的药物中,老年组和中青年组应用最多的均为中药(5...

     

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  • 出版日期:  2017-03-20
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