卵圆细胞介导肝脏再生信号通路的研究进展

钟小毛; 韩宝生

doi:10.3969/j.issn.1001-5256.2016.12.037

卵圆细胞介导肝脏再生信号通路的研究进展

DOI: 10.3969/j.issn.1001-5256.2016.12.037

华北理工大学附属医院唐山妇幼保健院生殖遗传科

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2016-12-20

Research advances in signaling pathways involved in liver regeneration mediated by oval cells

摘要

摘要: 肝细胞凋亡、坏死、衰老与卵圆细胞的激活和扩增密切相关,此外,卵圆细胞介导肝脏再生是肝损伤后再生的重要组成部分。目前已有多个实验证实了多种细胞因子、激素及神经递质参与此过程。回顾了近年研究结果,简要介绍TWEAK/Fn14、Hedgehog及甲状腺激素等多个信号通路与卵圆细胞介导肝脏再生的关系及研究进展,阐明各个信号通路在卵圆细胞介导肝脏再生中起的作用,了解其调节肝脏再生的机制,或许能对未来临床用药指明靶点。
- 卵圆细胞 /
- 肝再生 /
- 信号传导 /
- 综述
Abstract: The apoptosis,necrosis,and senescence of hepatocytes are closely associated with the activation and proliferation of oval cells,and in addition,liver regeneration mediated by oval cells is an important part of regeneration after liver injury. Currently,studies have shown that a variety of cytokines,hormones,and neurotransmitters are involved in this process. This article reviews recent research findings,introduces the research advances in the association between various signaling pathways( TWEAK/Fn14,Hedgehog,and thyroid hormone) and liver regeneration mediated by oval cells,elaborates on the role of each pathway in the regeneration of hepatocytes,and investigates related mechanisms in liver regeneration.
- hepatic oval cells /
- liver regeneration /
- signal transduction /
- review

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参考文献(32)

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