结直肠癌肝转移相关microRNA的研究现状

王东旭; 霍婷婷; 田耀文; 赵磊

doi:10.3969/j.issn.1001-5256.2016.12.034

结直肠癌肝转移相关microRNA的研究现状

DOI: 10.3969/j.issn.1001-5256.2016.12.034

1. 济南大学山东省医学科学院医学与生命科学学院
2. 山东大学附属山东省肿瘤医院肝胆外科
3. 郑州大学第一附属医院

基金项目:

国家自然科学基金资助项目(81272375)；

详细信息

中图分类号: R735.34
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- 被引次数: 0
出版历程
- 出版日期: 2016-12-20

Current status of research on microRNA associated with colorectal cancer liver metastasis

Research funding:

摘要

摘要: 肿瘤的转移是一个多步骤复杂的过程,肝转移是结直肠癌最常见的转移方式之一,对转移机制的理解和深入研究有助于寻求解决结直肠癌肝转移的方法,当前研究认为microRNA参与了肿瘤的转移与复发,通过对结直肠癌肝转移相关microRNA的研究,为疾病的发生发展、诊断治疗及预后等方面的研究提供了新的思路。归纳了结直肠癌肝转移相关microRNA的研究进展,回顾了microRNA的生物学功能以及分子机制,表明microRNA在肿瘤转移领域具有重要的意义,尤其在结直肠癌肝转移方面发挥着重要的作用。
- 结直肠肿瘤 /
- 肿瘤转移 /
- 微RNAs /
- 综述
Abstract: Tumor metastasis is a complicated process with multiple steps,and liver metastasis is the most common metastatic mode of colorectal cancer. Deep understanding and study of metastatic mechanism helps to find solutions for colorectal cancer liver metastasis. Recent studies have shown that microRNA are involved in tumor metastasis and recurrence,and studies on microRNA associated with colorectal cancer liver metastasis can provide new thoughts for the development and progression,diagnosis and treatment,and prognosis of the disease.This article summarizes the research advances in microRNA associated with colorectal cancer liver metastasis and reviews the biological function and molecular mechanism of microRNA,which suggests that microRNA have a vital significance in the field of tumor metastasis,especially colorectal cancer liver metastasis.
- colorectal neoplasms /
- neoplasm metastasis /
- microRNAs /
- review

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参考文献(41)

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