热休克蛋白70在肝细胞癌中的表达及作用

何泽玲; 曹建彪; 范公忍

doi:10.3969/j.issn.1001-5256.2016.11.047

热休克蛋白70在肝细胞癌中的表达及作用

DOI: 10.3969/j.issn.1001-5256.2016.11.047

1. 山西医科大学第二临床医学院
2. 解放军陆军总医院肝病治疗中心

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2016-11-20

Expression and role of heat shock protein 70 in hepatocellular carcinoma

摘要

摘要: 热休克蛋白(HSP)70在肝细胞癌(HCC)组织中呈不同程度的表达,其表达及调节机制尚不清楚,能否为HCC的早期诊断、治疗及预后提供帮助成为学者们研究的热点。从HSP70来源及家族、在HCC中的异常表达、与HCC各种治疗方法及其预后相关性等方面进行了综述,旨在为HCC的临床诊断及治疗提供帮助。
- 癌,肝细胞 /
- HSP70热休克蛋白质类 /
- 综述
Abstract: Heat shock protein 70( HSP70) is expressed differently in hepatocellular carcinoma( HCC) tissues. Since its expression and regulatory mechanism remain unclear,whether HSP70 can help with the early diagnosis,treatment,and prognostic evaluation of HCC has become a hot research topic. This article reviews the source of HSP70 and its family,abnormal expression of HSP70 in HCC,and its association with treatment methods and prognostic evaluation of HCC,in order to provide a reference for clinical diagnosis and treatment of HCC.
- carcinoma,hepatocellular /
- HSP70 heat-shock proteins /
- review

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参考文献(29)

[1]TORRE LA,BRAY F,SIEGEL RL,et al.Global cancer statistics,2012[J].CA Cancer J Clin,2015,65(2):87-108.

[2]WU MC,TANG ZY,LIU TH,et al.Evidence-based practice guidelines for the standardized pathological diagnosis of primary liver cancer in China(2015 update)[J].J Clin Hepatol,2015,31(6):833-839.(in Chinese)吴孟超,汤钊猷,刘彤华,等.原发性肝癌规范化病理诊断指南(2015年版)[J].临床肝胆病杂志,2015,31(6):833-839.

[3]BOSWELL-CASTEEL RC,JOHNSON JM,DUGGAN KD,et al.Overproduction and biophysical characterization of human HSP70 proteins[J].Protein Expr Purif,2015,106:57-65.

[4]RITOSSA F.A new puffing pattern induced by temperature shock and DNP in Drosophila[J].Cell Mol Life Sci,1962,18(12):571-573.

[5]LIANOS GD,ALEXIOU GA,MANGANO A,et al.The role of heat shock proteins in cancer[J].Cancer Lett,2015,360(2):114-118.

[6]KAMPINGA HH,HAGERMAN J,VOS MJ,et al.Guidelines for the nomenclature of the human heat shock proteins[J].Cell Stress Chaperones,2009,14(1):105-111.

[7]SWARTZ MA,IIDA N,ROBERTS EW,et al.Tumor microenvironment complexity:emerging roles in cancer therapy[J].Cancer Res,2012,72(10):2473-2480.

[8]GEHRMANN M,CERVELLO M,MONTALTO G,et al.Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis,liver cirrhosis,and hepatocellular carcinoma[J].Front Immunol,2014,5:307.

[9]HU H,QIU Y,GUO M,et al.Targeted Hsp70 expression combined with CIK-activated immune reconstruction synergistically exerts antitumor efficacy in patient-derived hepatocellular carcinoma xenograft mouse models[J].Oncotarget,2015,6(2):1079-1089.

[10]WANG WC,ZHOU YN.Research progress in tumor-associated antigen antibodies for diagnosis of liver cancer[J].J Clin Hepatol,2014,30(6):573-576.(in Chinese)王戊辰,周永宁.肿瘤相关抗原及抗体在肝癌诊断中的研究进展[J].临床肝胆病杂志,2014,30(6):573-576.

[11]CHUMA M,SAKAMOTO M,YAMAZAKI K,et al.Expression profiling in multistage hepatocarcinogenesis:identification of HSP70 as a molecular marker of early hepatocellular carcinoma[J].Hepatology,2003,37(1):198-207.

[12]TAKASHIMA M,KURAMITSU Y,YOKOYAMA Y,et al.Proteomic profiling of heat shock protein 70 family members as biomarkers for hepatitis C virus-related hepatocellular carcinoma[J].Proteomics,2003,3(12):2487-2493.

[13]GAO JL,YANG ZG,CHEN XR,et al.Analysis of association between HSP70 expression in tumor tissues and clinicopathological characteristics of HBV-related hepatocellular carcinoma[J].J Clin Hepatol,2015,31(5):733-736.(in Chinese)高加林,杨宗国,陈晓蓉,等.热休克蛋白70的表达与HBV相关肝细胞癌临床病理学特征的相关性分析[J].临床肝胆病杂志,2015,31(5):733-736.

[14]DI TOMMASO L,FRANCHI G,PARK YN,et al.Diagnostic value of HSP70,glypican 3,and glutamine synthetase in hepatocellular nodules in cirrhosis[J].Hepatology,2007,45(3):725-734.

[15]LIM SO,PARK SG,YOO JH,et al.Expression of heat shock proteins(HSP27,HSP60,HSP70,HSP90,GRP78,GRP94)in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules[J].World J Gastroenterol,2005,11(14):2072-2079.

[16]JOO M,CHI JG,LEE H.Expressions of HSP70 and HSP27in hepatocellular carcinoma[J].J Korean Med Sci,2005,20(5):829-834.

[17]SHIN E,RYU HS,KIM SH,et al.The clinicopathological significance of heat shock protein 70 and glutamine synthetase expression in hepatocellular carcinoma[J].J Hepatobiliary Pancreat Sci,2011,18(4):544-550.

[18]Ministry of Health of the People's Republic of China.Diagnosis,management,and treatment of hepatocellular carcinoma(V2011)[J].J Clin Hepatol,2011,27(11):1141-1159.(in Chinese)中华人民共和国卫生部.原发性肝癌诊疗规范(2011年版)[J].临床肝胆病杂志,2011,27(11):1141-1159.

[19]KIMURA F,ITOH H,AMBIRU S,et al.Circulating heatshock protein 70 is associated with postoperative infection and organ dysfunction after liver resection[J].Am J Surg,2004,187(6):777-784.

[20]LIU JG,LI Y,LIU D,et al.Expression and signficance of HSP70 and PI3K pathway in hepatocellular carcinoma[J/CD].Chin J Hepatic Surg:Electronic Edition,2013,2(1):45-52.(in Chinese)刘金钢,李岩,刘丹,等.HSP70与PI3K/Akt信号通路在肝细胞肝癌组织中的表达及意义[J/CD].中华肝脏外科手术学电子杂志,2013,2(1):45-52.

[21]MING WD.An experimental study on influence of percutaneous radiofrequency ablation for rabbit VX2 tumor on immune function[D].Beijing:Peking Union Med Coll,2014.(in Chinese)明韦迪.经皮射频消融兔VX2肿瘤对免疫功能影响的实验研究[D].北京:北京协和医学院,2014.

[22]RAI R,RICHARDSON C,FLECKNELL P,et al.Study of apoptosis and heat shock protein(HSP)expression in hepatocytes following radiofrequency ablation(RFA)[J].J Surg Res,2005,129(1):147-151.

[23]SCHUELLER G,KETTENBACH J,SEDIVY R,et al.Heat shock protein expression induced by percutaneous radiofrequency ablation of hepatocellular carcinoma in vivo[J].Int J Oncol,2004,24(3):609-613.

[24]HUANG JH,HE X,ZHANG XB,et al.Factors affected the clinical prognosis of liver cancer with radiofrenquency ablation therapy[J].J Mod Oncol,2011,19(11):2272-2275.(in Chinese)黄俊辉,何璇,张曦蓓,等.影响射频消融治疗大肝癌临床疗效的因素探讨[J].现代肿瘤医学,2011,19(11):2272-2275.

[25]MERCHANT S,KORBELIK M.Heat shock protein 70 is acute phase reactant:response elicited by tumor treatment with photodynamic therapy[J].Cell Stress Chaperones,2011,16(2):153-162.

[26]DUAN X,ZHOU G,ZHENG C,et al.Heat shock protein 70expression and effect of combined transcatheter arterial embolization and radiofrequency ablation in the rabbit VX2 liver tumour model[J].Clin Radiol,2014,69(2):186-193.

[27]DUAN XH.Heat shock protein 70 induces T cel antitumor immunity fol owing radiogrequency ablation combined with transcatheter arterial embolization in treating hepatic tumors[D].Wuhan:Huazhong Univ Sci&Technol,2012.(in Chinese)段旭华.HSP70介导RFA联合TAE治疗肝癌中T细胞免疫的实验研究[D].武汉:华中科技大学,2012.

[28]LAN Y,LI Y,LIANG Z,et al.A DNA vaccine against chimeric AFP enhanced by HSP70 suppresses growth of hepatocellular carcinoma[J].Cancer Immunol Immunother,2007,56(7):1009-1016.

[29]CHEN QL,TANG DX,LONG FX.Influencing signaling pathways of liver ancer angiogenesis[J].J Changchun Univ Chin Med,2015,31(4):844-846.(in Chinese)陈启亮,唐东昕,龙奉玺.影响肝癌血管生成的相关信号通路[J].长春中医药大学学报,2015,31(4):844-846.

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