转化生长因子β对肝星状细胞活化的调控作用

赵卫华; 王燕红; 丛敏

doi:10.3969/j.issn.1001-5256.2016.11.044

转化生长因子β对肝星状细胞活化的调控作用

DOI: 10.3969/j.issn.1001-5256.2016.11.044

首都医科大学附属北京友谊医院肝病中心肝硬化转化医学北京市重点实验室暨国家消化系统疾病临床医学研究中心

基金项目:

国家自然科学基金(81570542)；北京市自然科学基金(7142043)；北京市卫生系统高层次卫生技术人才学科骨干资助项目(2013-3-057)；

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2016-11-20

Regulatory effect of transforming growth factor-β on activation of hepatic stellate cells

Research funding:

摘要

摘要: 在肝纤维化过程中,TGFβ被认为是引起肝星状细胞(HSC)活化及细胞外基质产生的重要调控因子,因此,靶向TGFβ引起的HSC活化和肝纤维化的治疗策略值得深入研究。介绍了近几年来有关TGFβ对HSC的活化作用及其相关调控、靶向TGFβ活化HSC的治疗策略,以期为肝纤维化的临床治疗提供理论依据与新思路。
- 肝硬化 /
- 转化生长因子β /
- 肝星状细胞 /
- 综述
Abstract: In the process of liver fibrosis,transforming growth factor β( TGFβ) is considered an important regulatory factor for the activation of hepatic stellate cells( HSCs) and extracellular matrix production. Therefore,the therapeutic strategies targeted at the activation of HSCs and liver fibrosis induced by TGFβ are worthy of further research. This article reviews the role of TGFβ in the activation of HSCs,the regulatory effect of TGFβ,and the therapeutic strategies targeted at the activation of HSCs induced by TGFβ,so as to provide a theoretical basis and new thoughts for the clinical treatment of liver fibrosis.
- liver cirrhosis /
- transforming growth factor beta /
- hepatic stellate cells /
- review

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参考文献(31)

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