肝细胞内源性microRNA与HBV交互作用影响HBV转录的机制

邱华; 孙学华; 周振华; 李曼; 张鑫; 高月求

doi:10.3969/j.issn.1001-5256.2016.11.042

肝细胞内源性microRNA与HBV交互作用影响HBV转录的机制

DOI: 10.3969/j.issn.1001-5256.2016.11.042

1. 上海中医药大学附属曙光医院
2. 广西中医药大学第一附属医院

基金项目:

国家自然科学基金青年科学基金(81303066)；广西自然科学基金青年基金(2013GXNSFBA019154)；广西教育厅课题(2013YB121)；

详细信息

中图分类号: R512.62
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出版历程
- 出版日期: 2016-11-20

Influence of interaction between endogenous miRNAs and hepatitis B virus in hepatocytes on hepatitis B virus transcription and related mechanisms

Research funding:

摘要

摘要: microRNA(miRNA)可参与转录后基因表达的调控,在调控HBV转录、复制中发挥着关键性作用。总结了肝细胞内具有抗HBV作用的miRNA及4种调控机制,HBV通过HBx及自身编码miRNA等影响肝细胞内源性miRNA表达,促进复制的机制。分析表明,肝细胞内源性miRNA与HBV交互作用构成一个复杂的调控网络,相互竞争调控的结果,决定了HBV转录的活性及疾病发展的趋势。深入研究肝细胞内源性miRNA与HBV交互作用影响HBV转录的机制,对探索新的抗HBV方法具有重要的意义。
- 微RNAs /
- 肝炎病毒,乙型 /
- 转录,遗传 /
- 综述
Abstract: MicroRNAs( miRNAs) may be involved in the regulation of gene expression after transcription and play important roles in regulating hepatitis B virus( HBV) transcription and replication. This article summarizes the miRNAs with an anti- HBV effect in hepatocytes and4 regulatory mechanisms,as well as the mechanisms through which HBV affects the expression of endogenous miRNAs in hepatocytes via HBx and self- coding miRNAs and promotes replication. The analyses show that the interaction between endogenous miRNAs and HBV in hepatocytes forms a complex regulatory network,competes for the results of regulation,and determines the activity of HBV transcription and the trend of disease progression. In- depth studies on the mechanisms of the influence of interaction between endogenous miRNA and HBV in hepatocytes on HBV transcription have great significance in exploring new anti- HBV methods.
- microRNAs /
- hepatitis B virus /
- transcription,genetic /
- review

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参考文献(38)

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