中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

自噬与肝再生关系的研究进展

韩伟佳 时红波 陈煜

引用本文:
Citation:

自噬与肝再生关系的研究进展

DOI: 10.3969/j.issn.1001-5256.2016.09.044
基金项目: 

国家自然科学基金(81300349); 北京市科技新星计划(Z131107000413016); 北京市自然科学基金(7144216); 北京市医院管理局临床医学发展专项经费资助(XM201308); 国家临床重点专科建设项目(WJWYA-2014-002); 科研基地建设-重大传染病防治协同创新中心(115215); 北京卫生系统高技术人才培养项目基金(2014-3-090,2013-3-071,2011-3-083); 

详细信息
  • 中图分类号: R575

Research progress in the role of autophagy in liver regeneration

Research funding: 

 

  • 摘要:

    自噬是细胞内的一种降解途径,通过形成自噬泡将细胞内生物大分子和受损细胞器运送至溶酶体进行降解,在维持肝脏功能的动态平衡中发挥着重要作用,肝脏通过自噬可消除异常肝细胞。回顾了自噬和肝细胞、非实质肝细胞以及肝干细胞增殖的密切关系,分析表明自噬可通过促进肝细胞、肝干细胞的增殖从而恢复肝脏的体积和功能,并能够适时终止,防止肿瘤的发生;而功能失调时,自噬可能通过增强非实质肝细胞的活化,进而抑制肝细胞再生,同时导致纤维化的发生和发展;肿瘤形成阶段,自噬在正常细胞向癌细胞转化的过程中发挥重要作用,肝细胞恶性再生被激活但不能适时终止。

     

  • [1]KONIARIS LG,MCKILLOP IH,SCHWARTZ SI,et al.Liver regeneration[J].J Am Coll Surg,2003,197(4):634-659.
    [2]KWON YJ,LEE KG,CHOI D.Clinical implications of advances in liver regeneration[J].Clin Mol Hepatol,2015,21(1):7-13.
    [3]SUN H,DAI CL.Cell autophagy and liver regeneration after portal vein embolism[J].Clin J Curr Adv Gen Surg,2014,17(12):964-967.(in Chinese)孙浩,戴朝六.细胞自噬与门静脉栓塞后肝再生[J].中国现代普通外科进展,2014,17(12):964-967.
    [4]CZAJA MJ,DING WX,DONOHUE TM Jr,et al.Functions of autophagy in normal and diseased liver[J].Autophagy,2013,9(8):1131-58.
    [5]CODOGNO P,MEIJER AJ.Autophagy in the liver[J].Hepatol,2013,59(2):389-391.
    [6]ZHAO K,YE XM.Research advances in autophagy and liver transplantation[J].Organ Transplant,2015,6(3):206-208.(in Chinese)赵坤,叶小鸣.自噬与肝移植的研究进展[J].器官移植,2015,6(3):206-208.
    [7] CLAVIEN PA,PETROWSKY H,DEOLIVEIRA ML,et al.Strategies for safer liver surgery and partial liver transplantation[J].N Engl J Med,2007,356(15):1545-1559.
    [8]TOSHIMA T,SHIRABE K,FUKUHARA T,et al.Suppression of autophagy during liver regeneration impairs energy charge and hepatocyte senescence in mice[J].Hepatology,2014,60(1):290-300.
    [9]ENKHBOLD C,MORINE Y,UTSUNOMIYA T,et al.Dysfunction of liver regeneration in aged liver after partial hepatectomy[J].J Gastroenterol Hepatol,2015,30(7):1217-1224.
    [10]KIM JS,WANG JH,BIEL TG,et al.Carbamazepine suppresses calpain-mediated autophagy impairment after ischemia/reperfusion in mouse livers[J].Toxicol Appl Pharmacol,2013,273(3):600-610.
    [11]FOURASCHEN SM,de RUITER PE,KWEKKEBOOM J,et al.m TOR signaling in liver regeneration:rapamycin combined with growth factor treatment[J].World J Transplant,2013,3(3):36-47.
    [12]NI HM,BOCKUS A,BOGGES N,et al.Activation of autophagy protects against acetaminophen-induced hepatotoxicity[J].Hepatology,2012,55(1):222-232.
    [13]DING WX,LI M,CHEN X,et al.Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice[J].Gastroenterology,2010,139(5):1740-1752.
    [14]NI HM,WILLIAMS JA,JAESCHKE H,et al.Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver[J].Redox Biol,2013,1:427-432.
    [15]NI HM,BOGGESS N,MCGILL MR,et al.Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury[J].Toxicol Sci,2012,127(2):438-450.
    [16]TAKAMURA A,KOMATSU M,HARA T,et al.Autophagy-deficient mice develop multiple liver tumors[J].Genes Dev,2011,25(8):795-800.
    [17]INAMI Y,WAGURI S,SAKAMOTO A,et al.Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells[J].J Cell Biol,2011,193(2):275-284.
    [18]PENG W,DU T,ZHANG Z,et al.Knockdown of autophagy-related gene LC3 enhances the sensitivity of Hep G2 cells to epirubicin[J].Exp Ther Med,2015,9(4):1271-1276.
    [19]TOSHIMA T,SHIRABE K,MATSUMOTO Y,et al.Autophagy enhances hepatocellular carcinoma progression by activation of mitochondrialβ-oxidation[J].J Gastroenterol,2014,49(5):907-916.
    [20]HUANG GM,JIANG QH,CAI C,et al.SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway[J].Cancer Lett,2015,358(2):180-190.
    [21]WANG Y,WU J,LIN B,et al.Galangin suppresses Hep G2 cell proliferation by activating the TGF-βreceptor/Smad pathway[J].Toxicology,2014,326:9-17.
    [22]QIU DM,WANG GL,CHEN L,et al.The expression of beclin-1,an autophagic gene,in hepatocellular carcinoma associated with clinical pathological and prognostic significance[J].BMC Cancer,2014,14:327.
    [23]SUN K,GUO XL,ZHAO QD,et al.Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats[J].Cell Death Dis,2013,4:e501.
    [24]HABEEB MA,VISHWAKARMA SK,BARDIA A,et al.Hepatic stem cells:a viable approach for the treatment of liver cirrhosis[J].World J Stem Cells,2015,7(5):859-865.
    [25]CHENG Y,WANG B,ZHOU H,et al.Autophagy is required for the maintenance of liver progenitor cell functionality[J].Cell Physiol Biochem,2015,36(3):1163-1174.
    [26]JUNG J,CHOI JH,LEE Y,et al.Human placenta-derived mesenchymal stem cells promote hepatic regeneration in CCl4-injured rat liver model via increased autophagic mechanism[J].Stem Cells,2013,31(8):1584-1596.
    [27]PARK M,KIM YH,WOO SY,et al.Tonsil-derived mesenchymal stem cells ameliorate CCl4-induced liver fibrosis in mice via autophagy activation[J].Sci Rep,2015,5:8616.
    [28]LI J,YANG B,ZHOU Q,et al.Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition[J].Carcinogenesis,2013,34(6):1343-1351.
    [29]CLAVIEN PA,PETROWSKY H,DEOLIVEIRA ML,et al.Strategies for safer liver surgery and partial liver transplantation[J].N Engl J Med,2007,356(15):1545-1559.
    [30]YAMADA Y,KIRILLOVA I,PESCHON JJ,et al.Initiation of liver growth by tumor necrosis factor:deficient liver regeneration in mice lacking type I tumor necrosis factor receptor[J].Proc Natl Acad Sci U S A,1997,94(4):1441-1446.
    [31]MOHAMMED FF,KHOKHA R.Thinking outside the cell:proteases regulate hepatocyte division[J].Trends Cell Biol,2005,15(10):555-563.
    [32]ZENG TS,LIU FM,ZHOU J,et al.Depletion of Kupffer cells attenuates systemic insulin resistance,inflammation and improves liver autophagy in high-fat diet fed mice[J].Endocr J,2015,62(7):615-626.
    [33]FUKADA H,YAMASHINA S,IZUMI K,et al.Suppression of autophagy sensitizes Kupffer cells to endotoxin[J].Hepatol Res,2012,42(11):1112-1118.
    [34]PEDIADITAKIS P,LOPEZ-TALAVERA JC,PETERSSEN B,et al.The processing and utilization of hepatocyte growth factor/scatter factor following partial hepatectomy in the rat[J].Hepatology,2001,34(4 Pt 1):688-693.
    [35]SANO K,ASANUMA-DATE K,ARISAKA F,et al.Changes in glycosylation of vitronectin modulate multimerization and collagen binding during liver regeneration[J].Glycobiology,2007,17(7):784-794.
    [36]SHAO XQ,XIAO SH.Liver fibrosis:pathogenesis and clinical diagnosis[J].World Chin J Dig,2011,19(3):268-274.(in Chinese)邵祥强,肖华胜.肝纤维化发病机制与临床诊断的研究进展[J].世界华人消化杂志,2011,19(3):268-274.
    [37]HE Y,ZHU J,HUANG Y,et al.Advanced glycation end product(AGE)-induced hepatic stellate cell activation via autophagy contributes to hepatitis C-related fibrosis[J].Acta Diabetol,2015,52(5):959-969.
    [38]GRACIA-SANCHO J,GUIXE-MUNTET S,HIDE D,et al.Modulation of autophagy for the treatment of liver diseases[J].Expert Opin Investig Drug,2014,23(7):965-977.
    [39]FU MY,HE YJ,LV X,et al.Transforming growth factorβ1 reduces apoptosis via autophagy activation in hepatic stellate cells[J].Mol Med Rep,2014,10(3):1282-1288.
    [40]ZHAN L,YANG Y,MA TT,et al.Transient receptor potential vanilloid 4 inhibits rat HSC-T6 apoptosis through induction of autophagy[J].Mol Cell Biochem,2015,402(1-2):9-22.
    [41]WANG QW,JIN W,CHANG CF,et al.Regulatory effect of autophagy on dendritic cells in liver regeneration in rats:an IPA-based analysis[J].Hereditas,2015,37(3):276-282.(in Chinese)王棋文,靳伟,常翠芳,等.基于IPA分析自噬对大鼠肝再生中树突状细胞的调节作用[J].遗传,2015,37(3):276-282.
  • 加载中
计量
  • 文章访问数:  1849
  • HTML全文浏览量:  15
  • PDF下载量:  414
  • 被引次数: 0
出版历程
  • 出版日期:  2016-09-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回