肝纤维化发生发展机制的研究现状

徐明翠; 张峰; 诸葛宇征

doi:10.3969/j.issn.1001-5256.2016.09.039

肝纤维化发生发展机制的研究现状

DOI: 10.3969/j.issn.1001-5256.2016.09.039

1. 南京医科大学鼓楼临床医学院消化科
2. 南京大学医学院附属鼓楼医院消化科

基金项目:

国家自然科学基金资助项目(81570550)；

详细信息

中图分类号: R575.2
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- 被引次数: 0
出版历程
- 出版日期: 2016-09-20

Current research status of mechanisms of the development and progression of liver fibrosis

Drum Tower Clinical Medical School of Nanjing Medical University

Research funding:

摘要

摘要:
肝纤维化是多种慢性肝病进展至肝硬化的中间过程,其严重的并发症影响着慢性肝病患者的预后,目前为止肝纤维化仍没有确切的治疗药物。从信号通路和分子机制方面对肝纤维化发生发展进行深入探讨,简述了TGFβ-Smad信号通路、血小板衍生生长因子信号通路、瘦素作用的信号通路、结缔组织生长因子作用的信号通路,及趋化因子、神经内分泌因子和血管生成在肝纤维化发生机制中的最新研究进展,以期增加对肝纤维化发生机制的认识,为基于肝纤维化发生机制的分子靶向药物研究提供理论依据。
- 肝硬化 /
- 信号传导 /
- 综述
Abstract:
Liver fibrosis is the intermediate process in the progression of various chronic liver diseases to liver cirrhosis,and its serious complications affect the prognosis of patients with chronic liver diseases. However,so far,there remain no effective drugs for the treatment of liver fibrosis. This article investigates the development and progression of liver fibrosis from the aspects of signaling pathways and molecular mechanisms and briefly introduces the latest research advances in the roles of signaling pathways,including transforming growth factor- β/Smad pathway,platelet- derived growth factor pathway,leptin signaling pathway,and connective tissue growth factor pathway,chemokines,neuroendocrine factors,and angiogenesis in the development of liver fibrosis,so as to enhance the knowledge of the development of liver fibrosis and provide a theoretical basis for the research on molecular- targeted drugs based on the pathogenesis of liver fibrosis.
- liver cirrhosis /
- signal transduction /
- review

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参考文献(39)

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