榄香烯联合肝动脉化疗栓塞术治疗原发性肝癌的Meta分析

欧志涛; 詹远京; 黄春明

doi:10.3969/j.issn.1001-5256.2016.09.023

榄香烯联合肝动脉化疗栓塞术治疗原发性肝癌的Meta分析

DOI: 10.3969/j.issn.1001-5256.2016.09.023

广州市第八人民医院消化内科

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中图分类号: R735.7
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出版历程
- 出版日期: 2016-09-20

Elemene combined with transcatheter arterial chemoembolization in treatment of primary liver cancer: a meta-analysis

Department of Gastroenterology, No.8 People′s Hospital in Guangzhou

摘要

摘要:
目的评价榄香烯联合肝动脉化疗栓塞术(TACE)治疗原发性肝癌(PLC)的近期、远期疗效及不良反应。方法两位评价员按相同的检索策略检索Pubmed、EMBASE、Cochrane Library、中国期刊全文数据库、万方数据库、中国生物医学文献数据库、维普期刊全文数据库中关于榄香烯联合TACE治疗PLC的临床研究,用Jadad质量评分法评价纳入文献的质量,用Review Manager 5.2软件进行Meta分析。结果共纳入9篇文献,487例患者。Meta分析的结果提示:榄香烯联合常规TACE组与常规TACE组比较,其有效率、疾病控制率及12、24个月生存率均提高,差异有统计学意义[有效率:相对危险度(RR)=1.43,95%可信区间(95%CI):1.23~1.67,P<0.001;疾病控制率:RR=1.22,95%CI:1.11~1.32,P<0.001;12个月生存率:RR=1.68,95%CI:1.22~2.31,P=0.001;24个月生存率:RR=2.91,95%CI:1.44~5.87,P=0.003];在不良反应发生率方面,榄香烯联合常规TACE组治疗PLC可...
- 肝肿瘤 /
- 榄香烯 /
- 化疗栓塞,治疗性 /
- 治疗 /
- Meta分析
Abstract:
Objective To investigate the short- term efficacy,long- term efficacy,and adverse effects of elemene combined with transcatheter arterial chemoembolization( TACE) in the treatment of primary liver cancer( PLC). Methods Pub Med,EMBASE,Cochrane Library,Chinese Scientific Journal Full- Text Database,Wanfang Data,CBM,and VIP were searched by two reviewers using the same search strategy for clinical studies on elemene combined with TACE in the treatment of PLC. The Jadad quality scoring system was used to assess the quality of the studies included,and Review Manager 5. 2 software was used for the meta- analysis. Results A total of 9 articles involving487 patients were included. The results of the meta- analysis showed that compared with the TACE group,the elemene- TACE group showed significant increases in the response rate,disease control rate,and 12- and 24- month survival rates( response rate: RR = 1. 43,95% CI: 1. 23- 1. 67,P < 0. 001; disease control rate: RR = 1. 22,95% CI: 1. 11- 1. 32,P < 0. 001; 12- month survival rate: RR = 1. 68,95% CI: 1. 22- 2. 31,P = 0. 001; 24- month survival rate: RR = 2. 91,95% CI: 1. 44- 5. 87,P = 0. 003). As for the incidence of adverse events,the elemene- TACE group showed a significant reduction in the incidence rate of abdominal pain( RR = 0. 59,95% CI: 0. 36-0. 98,P = 0. 04). Conclusion Compared with TACE alone,elemene combined with TACE might improve response rate,disease control rate,and survival rates and reduce adverse events in patients with liver cancer.
- liver neoplasms /
- elemene /
- chemoembolzation,therapeutic /
- therapy /
- Meta-analysis analysis

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