中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

重症肝病并发侵袭性真菌病的诊治

臧红 辛绍杰

引用本文:
Citation:

重症肝病并发侵袭性真菌病的诊治

DOI: 10.3969/j.issn.1001-5256.2016.09.012
详细信息
  • 中图分类号: R575;R519

Diagnosis and treatment of invasive fungal diseases in patients with severe liver diseases

  • 摘要:

    重症肝病并发侵袭性真菌病(IFD)是影响重症肝病患者预后的重要因素,其早期诊断仍是困扰临床医生的重要问题。临床最常见的4种IFDs是念珠菌病、曲菌病、隐球菌病以及肺孢子菌肺炎,在重症肝病患者临床诊疗过程中重视并发IFD的可能,尤其对存在高危因素的患者,及早发现、及时诊断、恰当治疗,对改善危重症肝病的预后至关重要。

     

  • [1]HASSAN EA,EL-REHIM AS,HASSANY SM,et al.Fungal infection in patients with end-stage liver disease:low frequency or low index of suspicion[J].Int J Infect Dis,2014,23:69-74.
    [2]THEOCHARIDOU E,AGARWAL B,JEFFREY G,et al.Early invasive fungal infections and colonization in patients with cirrhosis admitted to the intensive care unit[J].Clin Microbiol Infect,2016,22(2):189.e1-e7.
    [3]SCHMIEDEL Y,ZIMMERLI S.Common invasive fungal diseases:an overview of invasive candidiasis,aspergillosis,cryptococcosis,and Pneumocystis pneumonia[J].Swiss Med Wkly,2016,146:w14281.
    [4]MABEE CL,MABEE SW,KIRKPATRICK RB,et al.Cirrhosis:a risk factor for cryptococcal peritonitis[J].Am J Gastroenterol,1995,90(11):2042-2045.
    [5]BROWN GD,DENNING DW,GOW NA,et al.Hidden killers:human fungal infections[J].Sci Transl Med,2012,4(165):165rv13.
    [6]MEAN M,MARCHETTI O,CALANDRA T.Bench-to-bedside review:Candida infections in the intensive care unit[J].Crit Care,2008,12(1):204.
    [7]YAPAR N.Epidemiology and risk factors for invasive candidiasis[J].Ther Clin Risk Manag,2014,10:95-105.
    [8]ANAISSIE EJ,STRATTON SL,DIGNANI MC,et al.Pathogenic Aspergillus species recovered from a hospital water system:a 3-year prospective study[J].Clin Infect Dis,2002,34(6):780-789.
    [9]CHEN LY,KUO SC,WU HS,et al.Associated clinical characteristics of patients with candidemia among different Candida species[J].J Microbiol Immunol Infect,2013,46(6):463-468.
    [10]ALASTRUEY-IZQUIERDO A,MELLADO E,PELAEZ T,et al.Population-based survey of filamentous fungi and antifungal resistance in Spain(FILPOP Study)[J].Antimicrob Agents Chemother,2013,57(7):3380-3387.
    [11]RAMANA K,KANDI S,BHARATKUMAR P,et al.Invasive fungal infections:a comprehensive review[J].Am J Infect Dis Microbiol,2013,1(4):64-69.
    [12]GUSTOT T,MAILLART E,BOCCI M,et al.Invasive aspergillosis in patients with severe alcoholic hepatitis[J].J Hepatol,2014,60(2):267-274.
    [13]WU Z,LING Z,SHAO F,et al.Invasive pulmonary aspergillosis in patients with acute-on-chronic liver failure[J].J Int Med Res,2012,40(5):1958-1965.
    [14]KHALID A,CLOUGH LA,SYMONS RC,et al.Incidence and clinical predictors of ocular candidiasis in patients with Candida fungemia[J].Interdiscip Perspect Infect Dis,2014,2014:650235.
    [15]CLANCY CJ,NGUYEN MH.Finding the“missing 50%”of invasive candidiasis:how nonculture diagnostics will improve understanding of disease spectrum and transform patient care[J].Clin Infect Dis,2013,56(9):1284-1292.
    [16]TIAN Y,TANG XP,LI H.Pulmonary aspergillosis in patients with severe hepatitis:it's clinical features and treatments[J].Chin J Hepatol,2007,15(9):697-698.(in Chinese)田沂,唐晓鹏,李慧.重型肝炎合并肺曲霉感染的临床特点与治疗[J].中华肝脏病杂志,2007,15(9):697-698.
    [17]SALIBA F,DELVART V,ICHAP,Fungal infections after liver transplantation:outcomes and risk factors revisited in the MELD era[J].Clin Transplant,2013,27(4):e454-e461.
    [18]LUCIGNANO B,RANNO S,LIESENFELD O,et al.Multiplex PCR allows rapid and accurate diagnosis of bloodstream infections in newborns and children with suspected sepsis[J].J Clin Microbiol,2011,49(6):2252-2258.
    [19] MYLONAKIS E,CLANCY CJ,OSTROSKY-ZEICHNER L,et al.T2 magnetic resonance assay for the rapid diagnosis of candidemia in whole blood:a clinical trial[J].Clin Infect Dis,2015,60(6):892-899.
    [20]LACROIX C,GICQUEL A,SENDID B,et al.Evaluation of two matrix-assisted laser desorption ionization-time of flight mass spectrometry(MALDI-TOF MS)systems for the identification of Candida species[J].Clin Microbiol Infect,2014,20(2):153-158.
    [21]VINIKOOR MJ,ZOGHBY J,COHEN KL,et al.Do all candidemic patients need an ophthalmic examination?[J].Int J Infect Dis,2013,17(3):e146-e148.
    [22] SEGAL BH.Aspergillosis[J].N Engl J Med,2009,360(18):1870-1884.
    [23]MASCHMEYER G,HAAS A,CORNELY OA.Invasive aspergillosis:epidemiology,diagnosis and management in immunocompromised patients[J].Drugs,2007,67(11):1567-601.
    [24]DIMOPOULOS G,PIAGNERELLI M,BERRE J,et al.Disseminated aspergillosis in intensive care unit patients:an autopsy study[J].J Chemother,2003,15(1):71-75.
    [25]PFEIFFER CD,FINE JP,SAFDAR N.Diagnosis of invasive aspergillosis using a galactomannan assay:a meta-analysis[J].Clin Infect Dis,2006,42(10):1417-1427.
    [26]HE H,DING L,SUN B,et al.Role of galactomannan determinations in bronchoalveolar lavage fluid samples from critically ill patients with chronic obstructive pulmonary disease for the diagnosis of invasive pulmonary aspergillosis:a prospective study[J].Crit Care,2012,16(4):r138.
    [27]SLOAN DJ,PARRIS V.Cryptococcal meningitis:epidemiology and therapeutic options[J].Clin Epidemiol,2014,6:169-182.
    [28]SINGH N,HUSAIN S,de VERA M,et al.Cryptococcus neoformans infection in patients with cirrhosis,including liver transplant candidates[J].Medicine(Baltimore),2004,83(3):188-192.
    [29]KAUFFMAN CA,BERGMAN AG,SEVERANCE PJ,et al.Detection of cryptococcal antigen.Comparison of two latex agglutination tests[J].Am J Clin Pathol,1981,75(1):106-109.
    [30]CHERUVATTATH R,BALAN V.Infections in patients with end-stage liver disease[J].J Clin Gastroenterol,2007,41(4):403-411.
    [31]THOMAS CF,LIMPER AH.Pneumocystis pneumonia[J].N Engl J Med,2004,350(24):2487-2498.
    [32]DELORENZO LJ,HUANG CT,MAGUIRE GP,et al.Roentgenographic patterns of Pneumocystis carinii pneumonia in 104 patients with AIDS[J].Chest,1987,91(3):323-327.
    [33]GRUDEN JF,HUANG L,TURNER J,et al.High-resolution CT in the evaluation of clinically suspected Pneumocystis carinii pneumonia in AIDS patients with normal,equivocal,or nonspecific radiographic findings[J].AJR Am J Roentgenol,1997,169(4):967-975.
    [34]CHOE PG,KANG YM,KIM G,et al.Diagnostic value of direct fluorescence antibody staining for detecting Pneumocystis jirovecii in expectorated sputum from patients with HIV infection[J].Med Mycol,2014,52(3):326-330.
    [35]AVINAO LJ,NAYLOR SM,ROECKER AM.A review of pneumocystis jirovecii pneumonia in the non-HIV-Infected population[J].Ann Pharmacother,2016,pii:1060028016650107.[Epub ahead of print]
    [36]KARAGEORGOPOULOS DE,QU JM,KORBILA IP,et al.Accuracy of beta-D-glucan for the diagnosis of Pneumocystis jirovecii pneumonia:a meta-analysis[J].Clin Microbiol Infect,2013,19(1):39-49.
    [37]LI M,LIAO WQ.The situation in the treatment of invasive fungal infections[J].Chin J Mycol,2012,7(1):47-51.(in Chinese)李梦,廖万清.侵袭性真菌感染治疗新进展[J].中国真菌学杂志,2012,7(1):47-51.
    [38]CORNEY OA,BASSETTI M,CALANDRA T,et al.ESCMID guideline for the diagnosis and management of Candida diseases2012:non-neutropenic adult patients[J].Clin Microbiol Infect,2012,18(Suppl 7):19-37.
    [39]REBOLI AC,ROTSTEIN C,PAPPAS PG,et al.Anidulafungin versus fluconazole for invasive candidiasis[J].N Engl J Med,2007,356(24):2472-2482.
    [40]PAPPAS PG,KAUFFMAN CA,ANDES DR,et al.Clinical practice guideline for the management of candidiasis:2016 update by the Infectious Diseases Society of America[J].Clin Infect Dis,2016,62(4):e1-e50.
    [41] WALSH TJ,ANAISSIE EJ,DENNING DW,et al.Treatment of aspergillosis:clinical practice guidelines of the Infectious Diseases Society of America[J].Clin Infect Dis,2008,46(3):327-360.
    [42] VERMEULEN E,MAERTENS J,de BEL A,et al.Nationwide surveillance of azole resistance in aspergillus diseases[J].Antimicrob Agents Chemother,2015,59(8):4569-4576.
    [43]PERFET JR,DISMUKES WE,DROMER F,et al.Clinical practice guidelines for the management of cryptococcal disease:2010 update by the infectious diseases society of america[J].Clin Infect Dis,2010,50(3):291-322.
    [44]PAPPAS PG.Cryptococcal infections in non-HIV-infected patients[J].Trans Am Clin Climatol Assoc,2013,124:61-79.
    [45] KAUFFMAN CA,PAPPAS PG,SOBEL J,et al.Essentials of clinical mycology[M].New York:Springer,2011.
    [46]HELWEG-LARSEN J,BENFIELD T,ATZORI C,et al.Clinical efficacy of first-and second-line treatments for HIV-associated Pneumocystis jirovecii pneumonia:a tri-centre cohort study[J].J Antimicrob Chemother,2009,64(6):1282-1890.
  • 加载中
计量
  • 文章访问数:  2363
  • HTML全文浏览量:  40
  • PDF下载量:  519
  • 被引次数: 0
出版历程
  • 出版日期:  2016-09-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回