Research advances in radiological examination for nonalcoholic fatty liver disease
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摘要: 非酒精性脂肪性肝病(NAFLD)在全球范围内高度流行,早期诊断及评估肝脏脂肪变性程度和纤维化程度对NAFLD患者的早期治疗和预后判断具有重要意义。总结了各种影像学新技术应用于NAFLD肝脏脂肪定量和纤维化预测的原理、诊断准确性、影响因素及实用性。研究显示基于超声和磁共振的影像学脂肪定量诊断技术及基于弹性成像的肝纤维化评估均表现出相当高的准确性,具有极大的应用前景,但这些技术仍需要进一步研究确定规范化的界值及操作流程以期为临床应用提供参考。Abstract: There is a high prevalence of nonalcoholic fatty liver disease( NAFLD) around the world,and early diagnosis and evaluation of liver fatty degeneration and fibrosis degree play important roles in the early treatment and prognostic evaluation of patients with NAFLD. This article reviews the principles,diagnostic accuracy,influencing factors,and practicability of various imaging techniques applied in liver fat quantification and fibrosis prediction. Studies have shown that radiological fat quantitative diagnosis based on ultrasound and magnetic resonance and liver fibrosis evaluation based on elastography have a high level of accuracy and promising prospects; however,such techniques lack standard cut- off values and operating procedures which may provide a reference for clinical application.
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Key words:
- fatty liver /
- fibrosis /
- ultrasonography /
- magnetic resonance imaging
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