代谢类药物治疗和预防原发性肝癌的研究进展

刘彦; 叶楠; 龚建平

doi:10.3969/j.issn.1001-5256.2016.07.046

代谢类药物治疗和预防原发性肝癌的研究进展

DOI: 10.3969/j.issn.1001-5256.2016.07.046

1. 成都市第五人民医院消化内科
2. 重庆医科大学附属第二医院肝胆外科

基金项目:

国家自然科学基金(31370753)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2016-07-20

Research advances in prevention and treatment of primary liver cancer with metabolic agents

Research funding:

摘要

摘要: 近年来,研究发现原发性肝癌(以下简称肝癌)的发生发展与人体代谢有着密切关系,人体代谢障碍增加肝癌的发生率及病死率。通过改善代谢类药物来预防及治疗肝癌是当今一大研究热点。简要介绍了S腺苷蛋氨酸、二甲双胍及他汀类3种可用来预防和治疗肝癌的代谢类药物,包括它们与肝癌发生的关系及其作用机制。认为需要进一步研究代谢与肝癌发生之间的关系,未来可以发现更多的代谢类药物来预防及治疗肝癌。
- 肝肿瘤 /
- 抗代谢药,抗肿瘤 /
- 综述
Abstract: Recently,more and more studies have shown that the development and progression of primary liver cancer( hereinafter referred to as liver cancer) is closely associated with the metabolism in human body,and metabolic disturbance in human body increases the incidence and mortality of liver cancer. The prevention and treatment of liver cancer with drugs improving metabolism is a hot research topic nowadays.This article introduces three metabolic agents,S- Adenosylmethionine,metformin,and statins,which can be used for the prevention and treatment of liver cancer,as well as their association with the pathogenesis of liver cancer and possible mechanisms of action. The article points out that further studies are needed to investigate the association between metabolism and the pathogenesis of liver cancer,in order to find more metabolic agents for the prevention and treatment of liver cancer in future.
- liver neoplasms /
- antimetabolites /
- antineoplastic

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参考文献(36)

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