抗-HBc检测方法的研究进展

王慰; 赵召霞; 李昱晓; 戎军; 高朋彬; 郑欢伟; 赵彩彦

doi:10.3969/j.issn.1001-5256.2016.07.043

抗-HBc检测方法的研究进展

DOI: 10.3969/j.issn.1001-5256.2016.07.043

1. 河北省石家庄市第五医院感染三科
2. 河北省石家庄市第五医院检验科
3. 河北医科大学第三医院感染科

基金项目:

河北省科技成果重点推广计划(13277765D)；

详细信息

中图分类号: R512.62
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出版历程
- 出版日期: 2016-07-20

Research advances in determination of hepatitis B core antibody level

Research funding:

摘要

摘要: 随着近几年双抗原夹心法定量检测抗-HBc的发展和应用,人们对抗-HBc在反映机体抗病毒能力方面的认识越来越多。简述了抗-HBc目前常用的检测方法和抗-HBc检测的新趋势,总结了血清中抗-HBc的水平与病毒抗原和机体的免疫应答状态有关,以及在抗病毒治疗前检测基线抗-HBc可有效预测抗病毒疗效等方面取得的研究进展。指出仍需深入研究抗-HBc在临床中的应用价值。
- 肝炎抗体,乙型 /
- 综述
Abstract: With the development and application of the double antigen sandwich method for quantification of hepatitis B core antibody( HBcAb) in recent years,there is increasing knowledge of the ability of HBcAb to reflect the body's anti- viral capability. This article introduces the commonly used measurement methods for HBcAb and the new trends in HBcAb measurement and summarizes the association of serum HBcAb level with viral antigen and the body's immune response,as well as research advances in effective prediction of antiviral effect with baseline HBcAb measurement before antiviral therapy. It is also pointed out that the clinical application of HBcAb needs further investigation.
- hepatitis B antibodies /
- review

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参考文献(20)

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