滤泡辅助性T淋巴细胞及其在肝脏疾病发生发展中的作用

纪龙珊; 孙学华; 周振华; 张鑫; 高亚婷; 高月求; 李曼

doi:10.3969/j.issn.1001-5256.2016.06.050

滤泡辅助性T淋巴细胞及其在肝脏疾病发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2016.06.050

上海中医药大学附属曙光医院肝病科上海市中医临床重点实验室

基金项目:

国家艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2012ZX10005004-002)；国家自然科学基金面上项目(81473477)；上海市进一步加快中医药事业发展三年行动计划(ZYSNXD-CC-ZDYJ105,ZY3-CCCX-3-3027)；上海市卫生局优秀青年人才培养项目(XYQ2013093)；

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中图分类号: R575
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出版历程
- 出版日期: 2016-06-20

Role of follicular helper T cells in development and progression of liver diseases

Research funding:

摘要

摘要: 滤泡辅助性T淋巴细胞（TFH）是近年来发现的辅助B淋巴细胞产生抗体的新型CD4+T淋巴细胞亚群,与肝脏疾病的发生发展密切相关。综述了TFH的发现、分化及相关的功能分子,通过产生白细胞介素21辅助B淋巴细胞产生抗体的机制,及在慢性乙型肝炎、慢性丙型肝炎、自身免疫性肝炎、原发性胆汁性肝硬化、肝衰竭、肝移植等肝脏疾病发生发展中的作用。指出TFH可能成为治疗肝脏疾病的新型靶细胞。
- 肝疾病 /
- T淋巴细胞,辅助诱导 /
- 综述
Abstract: Follicular helper T cell(TFH) is a new CD4+T lymphocyte subset which helps B lymphocytes to produce antibodies and is closely related to the development and progression of liver diseases.This article reviews the detection and differentiation of TFH and related functional molecules,the mechanism of action of TFH in helping B lymphocytes to produce antibodies through producing interleukin- 21,as well as the role of TFH in liver diseases such as chronic hepatitis B,chronic hepatitis C,autoimmune hepatitis,primary biliary cirrhosis,hepatic failure,and liver transplantation,and points out that TFH may become the new target cell in the treatment of liver diseases.
- liver diseases /
- T-lympholytes /
- helper-inducer

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参考文献(45)

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