肝脏缺血再灌注损伤机制及干预的研究进展

王清卿; 赵鑫; 陈玉超; 窦剑

doi:10.3969/j.issn.1001-5256.2016.06.049

肝脏缺血再灌注损伤机制及干预的研究进展

DOI: 10.3969/j.issn.1001-5256.2016.06.049

河北医科大学第三医院肝胆外科

基金项目:

河北省重大医学科研课题(zd2013031)；

详细信息

中图分类号: R575
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- 被引次数: 0
出版历程
- 出版日期: 2016-06-20

Research advances in mechanisms and intervention of hepatic ischemia-reperfusion injury

Research funding:

摘要

摘要: 肝脏缺血再灌注损伤(HIRI)是一个多因素共同作用的过程,在一定程度上制约了肝脏外科的发展。深入研究HIRI的机制,制订合理的干预治疗策略,对提高患者预后起着积极的作用。介绍了HIRI的相关发生机制,主要涉及钙超载、Kupffer细胞、微循环障碍、活性氧的产生、补体、非编码RNA以及各种细胞因子等多种因素,各个因素共同作用,导致肝细胞的坏死、凋亡。此外,自噬作为第二类细胞死亡方式,也参与了HIRI。鉴于HIRI的机制复杂,涉及因素众多,需从多方面着手干预。指出随着缺血预处理、亚低温以及氢气等干预方法的出现,新型的治疗方法有望为临床干预HIRI治疗带来新的思路。
- 肝疾病 /
- 再灌注损伤 /
- 综述
Abstract: Hepatic ischemia- reperfusion injury(HIRI) is a process caused by the combined effect of various factors,and to some extent,it limits the development of liver surgery.In- depth studies on mechanisms of HIRI and the development of reasonable therapeutic strategies have positive effects on the prognosis of patients.This article introduces the pathogenesis of HIRI,including calcium overload,Kupffer cells,microcirculation disturbance,production of reactive oxygen species,complement,non- coding RNA,and various cytokines,and the combined effect of these factors induces the necrosis and apoptosis of hepatocytes.In addition,as a second mode of cell death,autophagy is also involved in HIRI.Due to the complex mechanism of HIRI and many factors involved,intervention should be given from various aspects.This article points out that with the development of intervention such as ischemic pretreatment,mild hypothermia and hydrogen,the new therapeutic methods are expected to bring new thoughts to the clinical intervention of HIRI.
- liver diseases /
- reperfusion injury /
- review

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参考文献(38)

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