西安及周边地区HCV基因型构成分析

叶传涛; 赵洁茹; 郑煦阳; 边培育; 贾战生

doi:10.3969/j.issn.1001-5256.2016.06.030

西安及周边地区HCV基因型构成分析

DOI: 10.3969/j.issn.1001-5256.2016.06.030

第四军医大学唐都医院传染科

基金项目:

十二五传染病重大专项(2013ZX10004609)；

详细信息

中图分类号: R512.63
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出版历程
- 出版日期: 2016-06-20

Research funding:

摘要

摘要: <正>HCV可分为6个主要类型（1、2、3、4、5和6型）,每个类型又可以继续分为多种亚型[1]。HCV基因组高突变率的特点极大的阻碍了疫苗及治疗性抗体的研发。中国现行HCV标准治疗方案主要依赖于聚乙二醇干扰素（PEG-IFN）联合利巴韦林[2],但随着新的直接抗病毒药物（direct acting antiviral agents,DAA）的研发及临床运用,病毒清除率得到极大的提高,HCV NS5蛋白酶抑制剂——索非布韦（sofosbuvir）能够有效抑
- 肝炎病毒属 /
- 基因型 /
- 年龄分布 /
- 性别分布
- hepacivirus /
- genotype /
- age distribution /
- sex distribution

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参考文献(11)

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[9]LIU LJ,ZHANG R,LI JQ,et al.Hepatitis C virus genotype distribution in south and south west of China[J].Chin J Mod Med,2007,17(19):2337-2340.(in Chinese)刘丽君,张瑞,李俊强,等.中国南部和西南地区HCV感染的基因型分布特征[J].中国现代医学杂志,2007,17(19):2337-2340.

[10]ZHANG YF,ZHAO DM,ZHANG YM,et al.An analysis of related factors for hepatitis C genotyping and sustained virologic response in Xingtai,China[J].J Clin Hepatol,2015,31(11):1845-1848.(in Chinese)张彦芳,赵冬梅,张彦敏,等.邢台地区HCV基因型分布特征及其与疾病进展和持续病毒学应答的关系[J].临床肝胆病杂志,2015,31(11):1845-1848.

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