肝硬化合并门静脉血栓的研究现状

熊静平; 张跃新

doi:10.3969/j.issn.1001-5256.2016.06.010

肝硬化合并门静脉血栓的研究现状

DOI: 10.3969/j.issn.1001-5256.2016.06.010

1. 新疆医科大学第一附属医院感染疾病中心
2. 新疆医科大学第二附属医院消化科
3. 省部共建国家重点实验室培育基地-新疆重大疾病医学重点实验室

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2016-06-20

Current research on liver cirrhosis with portal vein thrombosis

摘要

摘要: 肝硬化是门静脉血栓(PVT)患者常见病因之一,肝硬化合并PVT易出现顽固性腹水、上消化道出血、肠坏死等并发症。可导致严重的后果而危及患者生命。在对PVT的概述基础上,论述了肝硬化阶段PVT形成的原因、机制,PVT的诊断、治疗及目前仍然存在争议的问题。
- 肝硬化 /
- 静脉血栓形成 /
- 诊断 /
- 治疗
Abstract: Liver cirrhosis is a common cause of portal vein thrombosis(PVT),and the patients with liver cirrhosis complicated by PVT tend to experience complications such as intractable ascites,upper gastrointestinal bleeding,and intestinal necrosis,which may lead to serious consequences and threaten the patient's life.This article briefly overviews PVT and discusses the reasons and mechanisms of the development of PVT during liver cirrhosis,as well as the diagnosis and treatment of PVT and related controversial issues.
- liver cirrhosis /
- venous thrombosis /
- diagnosis /
- therapy

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参考文献(25)

[1]HALL TC,CARCEA G,METCAFE M,et al.Management of acute non-cirrhotic and non-malignant portal vein thrombosis:a systematic review[J].World J Surg,2011,35(11):2510-2520.

[2]JAMES AW,RABL C,WESTPHALEN AC,et al.Portomesenteric venous thrombosis after laparoscopic surgery:a systematic literature review[J].Arch Surg,2009,144(6):520-526.

[3]AMITRANO L,GUARDASCIONE MA,BRANCACCIO V,et al.Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis[J].J Hepatol,2004,40(5):736-741.

[4]CONDAT B,PESSIONE F,DENNINGER HM,et al.Recent portal or mesenteric venous thrombosis:increased recognition and frequent recanalization on anticoagulant therapy[J].Hepatology,2000,32(3):466-470.

[5]HANDA P,CROWTHER M,DOUKETIS JD.Portal vein thrombosis:a Clinician-Oriented and practical review[J].Clin Appl Thromb Hemost,2013,20:498-506.

[6]BATTISTELLI S,CORATTI F,GORI T.Porto-spleno-mesenteric venous thrombosis[J].Int Angiol,2011,30(1):1-11.

[7]CONG YL,WEI YX,ZHANG LW,et al.The relationship between hemostatic changes in liver cirrhosis patients with different degrees of liver lesions in reference to Child-Pugh scores[J].Chin J Hepatol,2005,13(1):31-34.(in Chinese)丛玉隆,魏玉香,张立文,等.肝硬化患者凝血、抗凝及纤溶指标的变化与Child-Pugh分级的关系[J].中华肝脏病杂志,2005,13(1):31-34.

[8]TRIPODI A,MANNUCCI PM.The coagulopathy of chronic liver disease[J].N Engl J Med,2011,365(2):147-156.

[9]LU XM,WANG ZN,YANG J.Significance of molecular markers of prethrombotic state in monitoring portal vein thrombosis in patients with liver cirrhosis[J].J Clin Hepatol,2015,31(3):404-406.(in Chinese)卢晓敏,王振宁,杨军.肝硬化患者血栓前状态分子标志物对门静脉血栓形成的监测意义[J].临床肝胆病杂志,2015,31(3):404-406.

[10]FRANCOZ C,BELLGHITI J,VILGRAIN V,et al.Splanchnic vein thrombosis in candidates for liver transplantation:usefulness of screening and anticoagulatio[J].Gut,2005,54(5):691-697.

[11]MEI B,ZHENG K,CHEN XP.Relationship between platelets membrane glucoprotein CD62P with thrombosis of portal vein after devascularization operation[J].Acta Med Univ Sci Technol Huazhong,2006,35(4):548-549.(in Chinese)梅斌,郑凯,陈孝平.断流术后门静脉血栓形成与血小板膜蛋白CD62P的关系[J].华中科技大学学报:医学版,2006,35(4):548-549.

[12]OISON MM,LLADA PB,APELGREN KN.Portal vein thrombosis[J].Surg Endosc,2003,17(8):1322-1325.

[13]CHEN GP,WANG JY,YU FH,et al.Expression of platelet membrane protein CD62P in patients with hepatic cirrhosis[J].Med JQilu,2013,28(5):441-442.(in Chinese)陈冠平,王家银,于凤华,等.肝硬化病人血小板膜蛋白CD62P表达及临床意义[J].齐鲁医学杂志,2013,28(5):441-442.

[14]WANG GP,ZHANG ZC,XIA CM.Influence of endoscopic therapy on tissue factor pathway inhibitor and coagulation function in patients with gastrointestinal bleeding[J].J Radioimmunol,2013,26(4):521-522.(in Chinese)王国平,张忠臣,夏晨梅.内镜治疗对消化道出血患者组织因子途径抑制剂及凝血功能的影响[J].放射免疫学杂志,2013,26(4):521-522.

[15]PONZIANI FR,ZOCCO MA,CAMPANALE C,et al.Portal vein thrombosis:insight into physiopathology,diagnosis,and treatment[J].World J Gastroenterol,2010,16(2):143-155.

[16]AMITRANO L,BRANCACCIO V,GUARDASCIONE MA,et al.Inherited coagulation disorders in cirrhotic patients with pontal vein thrombosis[J].Hepatology,2000,31(2):345-348.

[17]de BRUIJNE EL,DARWISH MS,de MAAT MP,et al.Genetic variation in thrombin-activatable fibrinolysis inhibitor(TAFI)is associated with the risk of sp Ianchnic vein thrombosis[J].Thromb Haemost,2007,97(2):181-185.

[18]MARLINELLI I,PRIMIGNANI M,AGHEMO A,et al.High levels of factor VIII and risk of extra-hepatic portal vein obstruction[J].J Hepatol,2009,50(5):916-922.

[19]KUANG DP,YANG WZ.Research advances in liver cirrhosis complicated by portal vein thrombosis[J].Chin Hepatol,2013,18(2):119-121.(in Chinese)匡大鹏,杨文卓.肝硬化合并门静脉血栓形成的研究进展[J].肝脏,2013,18(2):119-121.

[20]WU XF,LU Y,LIU JZ,et al.Diagnostic value of ultrasound findings in postoperative portal vein thrombosis in patients with portal hypertension[J].Guide China Med,2014,12(7):131-132.(in Chinese)吴小凤,陆洋,刘继章,等.超声对门静脉高压症术后并发门静脉系统血栓的诊断价值[J].中国医药指南,2014,12(7):131-132.

[21]LAI W,LU SC,LI GY,et al.Anticoagulation therapy prevents portal-splenic vein thrombosis after splenec-tomy with gastroesophageal devascularization[J].World J Gastroenterol,2012,18(26):3443-3450.

[22]SENZOLO M,M SARTORI T,ROSSETTO V,et al.Prospective evaluation of anticoagulation and transjugular intrahepatic portosys temic shunt for the management of portal vein thrombosis in cirrhosis[J].Liver Int,2012,32(6):919-927.

[23]ENGLESBE MJ,SCHAUBEL DE,CAI S,et al.Portal vein thrombosis and liver transplant survival benefit[J].Liver Transplantation,2010,16(8):999-1005.

[24]DOENECKE A,TSUI TY,ZUELKE C,et al.Pre-existent portal vein.thrombosis in liver transplantation:influence of pre-operative.disease severity[J].Clin Transplant,2010,24(1):48-55.

[25]FRANCOZ C,DOMINIQUE V,FRANCOIS D.Portal vein throm-bosis,cirrhosis,and liver transplantation[J].J Hepatol,2012,57(1):203-212.

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