自噬在肝脏细胞中的作用及其受MAPK通路调节的研究进展

姜娜; 平键; 徐列明

doi:10.3969/j.issn.1001-5256.2016.05.048

自噬在肝脏细胞中的作用及其受MAPK通路调节的研究进展

DOI: 10.3969/j.issn.1001-5256.2016.05.048

1. 上海中医药大学附属曙光医院
2. 上海中医药大学肝病研究所
3. 肝肾疾病病证教育部重点实验室
4. 上海市中医临床重点实验室
5. 国家中医药管理局重点研究室(慢性肝病虚损)

基金项目:

国家自然科学基金项目(81373859)；国家中医药管理局中医肝胆病重点学科(2010sh)；上海市教育委员会重点学科(第五期)建设项目(J50307)；上海市高校创新团队建设项目(第一期)；

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2016-05-20

Research advances in the role of autophagy in liver cells and regulation of MAPK pathway

Research funding:

摘要

摘要: 自噬是真核生物细胞内一种高度保守的细胞程序,在肝脏的营养和能量代谢中起着重要作用。促进肝细胞自噬,可保护细胞应对外界不良刺激,但若自噬过度,可以引起肝细胞自噬性细胞死亡。肝星状细胞(HSC)是肝纤维化发生、发展过程中一种重要细胞,自噬可为其活化提供能量,但也可能导致其死亡。简述了自噬与肝细胞、HSC的关系;介绍了近年来丝裂原活化蛋白激酶通路与自噬的关系,提出了深入研究肝纤维化过程中自噬与调节通路间的关系,可为研发抗肝纤维化药物提供新靶标的观点。
- 自噬 /
- 肝硬化 /
- 肝细胞 /
- 肝星状细胞 /
- 丝裂原激活蛋白激酶类 /
- 综述
Abstract: Autophagy is a highly conservative cellular process in eukaryotes that plays an important role in nutrition and energy metabolism in the liver. It can promote the autophagy of hepatocytes and protect the hepatocytes against the adverse external stimulation,but excessive autophagy can cause autophagic cell death of hepatocytes. Hepatic stellate cells( HSC) play an important role in the development and progression of liver fibrosis. Autophagy can provide energy for their activation,but may also lead to their death. This article introduces the relationship of autophagy with hepatocytes / HSC and the mitogen- activated protein kinase pathway,and points out that in- depth studies on the relationship between autophagy and pathway regulation during liver fibrosis can provide new targets for developing antifibrotic drugs.
- autophagy /
- liver cirrhosis /
- hepatocytes /
- hepatic stellate cells /
- mitogen-activated protein kinase /
- review

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参考文献(33)

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