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经肝动脉化疗栓塞术联合沙利度胺或索拉非尼治疗不可切除原发性肝癌的效果比较

郑康 何盟国 王智翔

引用本文:
Citation:

经肝动脉化疗栓塞术联合沙利度胺或索拉非尼治疗不可切除原发性肝癌的效果比较

DOI: 10.3969/j.issn.1001-5256.2016.05.017
详细信息
  • 中图分类号: R735.7

Therapeutic effect of transcatheter arterial chemoembolization combined with thalidomide or sorafenib in treatment of unresectable primary liver cancer: a comparative analysis

  • 摘要:

    目的探讨经肝动脉化疗栓塞术(TACE)联合沙利度胺及TACE联合索拉非尼两种化疗方式对不可切除性原发性肝癌患者的治疗效果。方法收集2012年1月-2013年8月在陕西省核工业215医院进行两种方式治疗的原发性肝癌患者102例作为研究对象,随机分为TACE联合沙利度胺组(49例)和TACE联合索拉非尼组(53例),对其近期疗效、远期疗效、治疗前后相关化验指标变化及不良反应进行评价。计量资料组间比较采用成组t检验,组内比较采用配对t检验,计数资料组间比较采用χ2检验,采用生存曲线对生存数据进行分析,并采用Log-Rank检验进行比较。结果两组在客观缓解率、疾病控制率等近期疗效方面差异均无统计学意义(P值均>0.05)。两组患者的2年生存率差异有统计学意义(χ2=4.692,P=0.03)。两组患者总生存时间及中位无疾病进展生存时间差异均有统计学意义(χ2值分别为8.267、6.896,P值分别为0.004、0.009)。两组患者甲胎蛋白及GGT治疗后组间比较差异均有统计学意义(t值分别为2.035、2.843,P值分别为0.038、0.025)。两组患者在恶心呕吐、头晕头痛、皮疹脱屑...

     

  • [1]BHAYANI NH,JIANG Y,HAMED O,et al.Advances in the pharmacologic treatment of hepatocellular carcinoma[J].Curr Clin Pharmacol,2015,10(4):299-304.
    [2]GE JB,XU YJ.Internal medicine[M].8th.Beijing:People's Medical Publishing House,2013:429.(in Chinese)葛均波,徐永健.内科学[M].8版.北京:人民卫生出版社,2013:429.
    [3]YANG XF,LONG XD.Research advances in recurrence and metastasis of primary liver cancer[J].Henan J Surg,2012,18(2):80-83.(in Chinese)杨显富,龙先德.原发性肝癌复发转移的研究进展综述[J].河南外科学杂志,2012,18(2):80-83.
    [4]YE YJ,SHEN ZL,WANG S.Therapeutic concept and strategy of metastatic liver cancer[J].Chin J Oper Proc Gen Surg:Electronic Edition,2014,8(1):26-29.(in Chinese)叶颖江,申占龙,王杉.转移性肝癌的治疗理念和策略[J].中华普外科手术学杂志:电子版,2014,8(1):26-29.
    [5]Ministry of Health of the People's Republic of China.Diagnosis,management,and treatment of hepatocellular carcinoma(V2011)[J].J Clin Hepatol,2011,27(11):1141-1159.(in Chinese)中华人民共和国卫生部.原发性肝癌诊疗规范(2011年版)[J].临床肝胆病杂志,2011,27(11):1141-1159.
    [6]GAO S,ZHU X,YANG RJ,et al.TACE combined with hepatic arterial infusion chemotherapy using oxaliplatin,5-fluorouracil and folinic acid for intermediate and advanced hepatocellular carcinomas[J].J Intervent Radiol,2012,21(5):377-383.(in Chinese)高嵩,朱旭,杨仁杰,等.TACE联合奥沙利铂、氟尿嘧啶、亚叶酸钙肝动脉化疗治疗中晚期原发性肝癌[J].介入放射学杂志,2012,21(5):377-383.
    [7]DING J,DAI X,MENG XY,et al.Research advances in response evaluation criteria in solid tumors[J].Chin J Clin Oncol Rehabil,2015,22(9):1150-1152.(in Chinese)丁婕,戴旭,孟宪运,等.实体瘤疗效评价标准的研究进展[J].中国肿瘤临床与康复,2015,22(9):1150-1152.
    [8]LAN CH,WANG CY.Progress of TACE for primary liver cancer[J].Curr Physician,2009,15(23):500-502.(in Chinese)兰春虎,王常友.原发性肝癌TACE治疗进展[J].当代医学,2009,15(23):500-502.
    [9]COLOMBO M,SANGIOVANNI A.Treatment of hepatocellular carcinoma:beyond international guidelines[J].Liver Int,2015,35(1):129-138.
    [10]LEY AM,CHAU CH,FIGG WD.Structural studies reveal thalidomide's mechanism of action and clinical effects:crystal clear or clearly complexed?[J].Cancer Biol Ther,2015,16(1):19-20.
    [11]YU J,LIU F,SUN Z,et al.The enhancement of radiosensitivity in human esophageal carcinoma cells by thalidomide and its potential mechanism[J].Cancer Biother Radiopharm,2011,26(2):219-227.
    [12]GIRGIS E,MAHONEY J,DARLING-REED S,et al.Arsenic trioxde enhance the cytotoxic effect of thalidomide in a KG-la human acute mylogenous leukemia cell line[J].Oncol lett,2010,1(3):473-479.
    [13]PAN JQ,LU GP,YU ZJ.Thalidomide on anti-tumor research[J].Chin J Cancer Prev Treat,2012,19(7):552-555.(in Chinese)潘骥群,鲁光平,于志坚.沙利度胺抗肿瘤的研究进展[J].中华肿瘤防治杂志,2012,19(7):552-555.
    [14]NISHIDA N,KITANO M,SAKURAI T,et al.Molecular mechanism and prediction of sorafenib chemoresistance in human hepatocellular carcinoma[J].Dig Dis,2015,33(6):771-779.
    [15]ZHANG HJ,GUO WD.Research advances in sorafenib in treatment of tumors[J].Chin J Clinicians:Electronic Edition,2013,7(1):258-260.(in Chinese)张惠洁,郭卫东.索拉菲尼在肿瘤治疗中的研究进展[J].中华临床医师杂志:电子版,2013,7(1):258-260.
    [16]YANG M,QI XS,HAN GH.Sorafenib-related adverse events in treatment of hepatocellular carcinoma[J].J Clin Hepatol,2014,30(3):278-281.(in Chinese)杨曼,祁兴顺,韩国宏.索拉菲尼在肝癌治疗中的不良反应[J].临床肝胆病杂志,2014,30(3):278-281.
    [17]CHANG BX,XIN SJ.Recent advances in research on alpha-fetoprotein and its clinical application[J].World Chin J Dig,2010,18(6):576-580.(in Chinese)常彬霞,辛绍杰.甲胎蛋白及其临床应用研究进展[J].世界华人消化杂志,2010,18(6):576-580.
    [18]ZENG YL,MAO HN.The relationship between changes and prognosis of serum AFP,AKP,GGT in hepatocellular carcinoma after transcatheter hepatic arterial chemoembolization[J].China Trop Med,2011,11(11):1389-1405.(in Chinese)曾颖玲,毛惠南.血清AFP、AKP和GGT在肝癌化疗栓塞后的改变与预后的关系[J].中国热带医学,2011,11(11):1389-1405.
    [19]WAN XH,LU XF.Diagnostics[M].8th ed.Beijing:People's Medical Publishing House,2013:366-372.(in Chinese)万学红,卢雪峰.诊断学[M].8版.北京:人民卫生出版社,2013:366-372.
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  • 出版日期:  2016-05-20
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