不同来源间充质干细胞治疗肝纤维化的研究进展

王冬冬; 陈刚; 胡宗强; 李立

doi:10.3969/j.issn.1001-5256.2016.03.044

不同来源间充质干细胞治疗肝纤维化的研究进展

DOI: 10.3969/j.issn.1001-5256.2016.03.044

昆明市第一人民医院暨昆明医科大学附属甘美医院

基金项目:

云南省教育厅科学研究基金项目(2013C239)；

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2016-03-20

Research advances in mesenchymal stem cells from various sources in treatment of liver fibrosis

The First People′s Hospital of Kunming & The Affiliated Ganmei Hospital of Kunming Medical University

Research funding:

摘要

摘要: 间充质干细胞(MSC)是一种中胚层分化而来的干细胞,具有多向分化潜能。MSC通过旁分泌细胞因子及细胞间相互作用,可减轻肝纤维化并改善肝功能,但治疗机制尚未完全明确。MSC来源于多种组织,例如骨髓、脐带组织、脐带血、外周血及脂肪组织等;然而,不同来源的MSC,在肝纤维化的实验研究与临床治疗过程中,进展不一。概括了MSC减轻肝纤维化可能的作用机制以及近年来不同来源MSC在实验研究及临床应用等方面的进展。认为MSC移植作为治疗肝纤维化的一种新方式,具有广阔的应用前景。
- 间质干细胞 /
- 肝硬化 /
- 治疗 /
- 综述
Abstract: Mesenchymal stem cells( MSC) are derived from the mesoderm,and exhibit multipotential differentiation. MSC can alleviate liver fibrosis and improve liver function through paracrine cytokines and cell- cell interactions,but their therapeutic mechanism remains unknown. MSC are derived from various tissues,such as bone marrow,umbilical cord tissue,umbilical cord blood,peripheral blood,and adipose tissue. However,there are different advances in MSC with various sources in experimental studies and clinical treatment of liver fibrosis. This paper summarizes the possible therapeutic mechanisms of MSC in alleviating liver fibrosis,as well as the advances in experimental studies and clinical application of MSC with various sources. MSC transplantation is a new therapeutic method for liver fibrosis and has a broad application prospect in this field.
- mesenchymal stem cells /
- liver cirrhosis /
- therapy /
- review

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参考文献(35)

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