HBV父婴垂直传播的研究进展

张凯; 蔺淑梅; 杨雪亮; 孔颖; 刘小静; 张曦; 石磊; 陈云茹; 叶峰; 李娜

doi:10.3969/j.issn.1001-5256.2016.03.040

HBV父婴垂直传播的研究进展

DOI: 10.3969/j.issn.1001-5256.2016.03.040

1. 西安交通大学第一附属医院
2. 陕西省妇幼保健院

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中图分类号: R512.62
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出版历程
- 出版日期: 2016-03-20

Research advances in paternal- fetal vertical transmission during HBV infection

The First Affiliated Hospital of Xi′an Jiao Tong University

摘要

摘要: HBV感染是一个严重威胁人类健康的全球性公共卫生问题。父婴垂直传播（P-FT）是HBV持续感染的主要来源之一,其传播率与母婴垂直传播相当,近几年受到越来越多的关注,成为一个国内外研究的热点。P-FT通过精子途径传播已得到证实,但相关机制尚未阐明。研究显示父方血清、精液HBV DNA高载量及血清HBe Ag阳性是P-FT发生的主要危险因素。HBV DNA一旦随机整合入精子后可影响精子质量,引起男性不育,甚至可能影响母亲妊娠结局。目前孕前干预是阻断P-FT的最主要措施,包括父亲抗病毒治疗及母亲主动免疫。
- 肝炎,乙型 /
- 肝炎病毒,乙型 /
- 疾病传播,垂直 /
- 综述
Abstract: Hepatitis B virus( HBV) infection is a global public health problem which greatly threatens human health. Paternal- fetal vertical transmission( P- FT) is one of the leading causes of persistent HBV infection,and has a transmission rate similar to that of mother- to- child vertical transmission. In recent years,P- FT has been attracting more and more attention and has become a hot research topic at home and abroad. It has been confirmed that P- FT occurs via sperm,but the mechanism remains unknown. Studies have shown that a high HBV DNA load in serum and semen and positive serum HBe Ag are the major risk factors for the occurrence of P- FT. Random integration of HBV DNA into sperm can affect sperm quality,cause male infertility,and even affect the maternal pregnancy outcome. Currently the most important measure to block P- FT is pre- pregnancy intervention,including antiviral therapy for the father and active immunization for the mother.
- hepatitis B /
- hepatitis B virus /
- disease transmission,vertical /
- review

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参考文献(45)

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