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Infectious cell culture systems of hepatitis C virus and their application in drug development
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摘要:
利用从基于JFH1克隆的HCV嵌合体或者复制子中鉴定的适应性突变,已经建立了代表基因1~3型HCV的细胞感染模型。迄今,JFH1仍然是唯一能在肝细胞系中自主高效复制的克隆,因此迫切需要建立能培养所有HCV临床分离株的通用细胞感染模型。概述了建立HCV细胞感染模型的历程、现有细胞感染性克隆和支持HCV复制的细胞系,同时简述HCV细胞复制和感染模型在药物研究中的一些应用。
Abstract:To date,the infectious cell culture systems of hepatitis C virus( HCV) representative of genotypes 1-3 have been developed with the aid of adaptive mutations identified from JFH1-based chimera viruses or replicons. Nevertheless,JFH1 is still the unique clone capable of spontaneous replication in liver cell lines. It is an urgent need to develop a universal infectious cell culture system for any HCV clinical isolate. This article reviews the progress in HCV cell culture systems,existing infectious HCV clones,and permissive cell lines supporting HCV replication,as well as the application of HCV replication and infection model in drug development.
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Key words:
- hepalivirus /
- cells,culltured /
- antiviral agents
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