Intravoxel incoherent motion diffusion- weighted imaging( IVIM- DWI) can not only obtain various parameters,but also provide diffusion and perfusion information without contrast agents. IVIM- DWI could make up for the deficiency of traditional DWI and contrast enhancement methods. This paper introduces the basic principle of IVIM- DWI and its research progress and clinical significance in the diagnosis,prognosis,and treatment options for liver diseases,including hepatic steatosis,liver fibrosis,primary liver cancer,and focal liver lesions. This paper also summarizes the challenges confronting the clinical application of IVIM technology,including the determination of b- values,selection of mathematical models,and limitation from working platform conditions. The analyses demonstrate that the IVIM technology has been more and more widely used in clinical practice and scientific research. With continuous improvement in equipment conditions and further solution of technical problems,the IVIM technology will make a greater contribution to the assessment of liver diseases in an accurate,fast,and noninvasive manner.