Objective To analyze the influencing factors for conversion of laparoscopic cholecystectomy to open surgery,and to provide a clinical reference for developing surgical procedures. Methods A total of 278 patients receiving laparoscopic cholecystectomy in our hospital from January 2009 to December 2013 were analyzed. Among them,31 patients were converted to open surgery during laparoscopic cholecystectomy,while the remaining 274 patients were not. The influencing factors for conversion to open surgery were investigated. The t test was applied in the comparison of continuous data,whereas the χ2test was used for categorical data. The univariate logistic regression analysis was performed to investigate significant influencing factors,and the independent influencing factors were determined by multivariate logistic regression analysis. Results The univariate analysis showed that sex( P = 0. 022),arteriosclerosis( P < 0. 001),diabetes( P < 0. 001),heart failure( P = 0. 002),previous upper abdominal surgery( P < 0. 001),age( P < 0. 001),body mass index( BMI)( P = 0. 003),gallbladder wall thickness( P < 0. 001),the count of white blood cells( P < 0. 001),and serum total bilirubin level( P = 0. 046) were significantly different between groups. The multivariate logistic regression analysis further showed that previous upper abdominal surgery( P <0. 001),sex( P = 0. 001),BMI( P = 0. 002),and the count of white blood cells( P = 0. 019) were independent influencing factors,among which previous upper abdominal surgery was the most significant one( OR = 4. 646,95% CI: 2. 012- 10. 729). Conclusion Previous upper abdominal surgery,sex,BMI,and the count of white blood cells were independent influencing factors for conversion of laparoscopic cholecystectomy to open surgery. Careful evaluation of these factors before surgery would help to increase the operation efficacy,possessing an important clinical value.