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Intrahepatic cholestasis: from pathogenesis to diagnosis and treatment
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摘要:
肝内胆汁淤积是临床上常见的肝损伤的表现形式,其病因较为复杂,所涉及的疾病种类广泛。其发病与肝细胞及毛细胆管细胞损害、胆汁酸转运障碍、胆汁流动异常等机制相关。肝内胆汁淤积的治疗方法以药物治疗为主,现主要的药物包括熊去氧胆酸、奥贝胆酸、腺苷蛋氨酸以及中药制剂等。现就肝内胆汁淤积的发病机制和治疗进展作一评述。
Abstract:Intrahepatic cholestasis is a manifestation of liver damage commonly seen in clinical practice,with a complex etiology and involvement of a wide range of diseases. Its pathogenesis is related to hepatocellular damage and bile capillary cell damage,bile acid transport disorder,and abnormal bile flow. The treatment of intrahepatic cholestasis mainly includes drug therapy,and major drugs include ursodeoxycholic acid,obeticholic acid,S- adenosyl methionine,and traditional Chinese medicine preparations. The pathogenesis and treatment of intrahepatic cholestasis are reviewed in this article.
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Key words:
- cholestasis,intrahepatic /
- diagnosis /
- therapy /
- editorial
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