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Research progress in culture and in vivo and in vitro HBV infection of primary hepatocytes of tree shrews
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摘要:
HBV感染是人类面临的重要健康问题,研究HBV的感染机制一直是这个领域的关键点,为开展HBV的相关研究,建立简单易得的HBV体内外感染模型是大势所趋。树鼩因与人和灵长类亲缘关系较近,使得HBV感染树鼩模型受到越来越多的关注。综述了国内外近年来树鼩体内外感染HBV的研究进展,特别是树鼩原代肝细胞体外培养的研究进展及取得的成绩,对未来的一些研究方向进行了展望。
Abstract:HBV is a major health problem faced by human beings. The study of the mechanism of HBV infection has been a key point in this field. To carry out the related research on HBV,establishment of simple and available in vivo and in vitro infection models is the trend. Due to the close relationship between tree shrews and human/primates,the tree shrew model of HBV infection has attracted more and more attention. This review summarizes recent research,both at home and abroad,about in vivo and in vitro HBV infection in tree shrews,especially the research progress in in vitro culture of primary hepatocytes of tree shrews,and looks to the future research directions as well.
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Key words:
- hepatitis B virus /
- tupaia /
- cell culture techniques /
- review
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