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胰腺局部肾素-血管紧张素系统经典轴ACE-AngⅡ-AT1及新轴ACE2-Ang（1-7）-Mas的表达及意义
DOI: 10.3969/j.issn.1001-5256.2015.09.049
Expression and significance of classical ACE-AngII-AT1 axis and new ACE2-Ang (1-7)-Mas axis of renin-angiotensin system in local pancreas
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摘要:
肾素-血管紧张素系统（RAS）是一种经典的循环酶通路,在胰腺功能活动调解中起着重要作用。近几年来随着人们对RAS的认识不断加深,发现RAS轴不仅包括经典轴ACE-AngⅡ-AT1轴,还包括新轴ACE2-Ang（1-7）-Mas轴。已有多项研究证实,ACE2-Ang（1-7）-Mas轴能对抗RAS经典轴的作用。综述了胰腺局部RAS两条轴各自的组成、功能及两者的比较分析。
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关键词:
- 胰腺 /
- 肾素-血管紧张素系统 /
- 血管紧张素类 /
- 肽基二肽酶A /
- 综述
Abstract:The renin-angiotensin system( RAS) is a classical circulating enzyme pathway that plays an important role in regulation of pancreatic function. In recent years,with deepening understanding of RAS,researchers found that RAS not only includes the classical ACE-Ang II-AT1 axis,but also includes the new ACE2-Ang( 1-7)-Mas axis. Extensive studies have confirmed that the ACE2-Ang( 1-7)-Mas axis can antagonize the effect of the ACE-Ang II-AT1 axis. This paper reviews the composition and function of both axes of the RAS in the local pancreas,and also presents the comparison between the two axes.
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Key words:
- pancreas /
- renin-angiotensin system /
- angiotensins /
- pepticly-clipeptidase /
- review
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