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Role of endoplasmic reticulum stress-mediated apoptosis in liver fibrosis
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摘要:
近年来研究发现,内质网应激(ERS)是器官纤维化发病机制中的共同环节。然而,目前ERS在肝纤维化发生发展过程中产生了哪些功能性的改变及其可能发挥的作用尚不明确。总结了ERS及其介导的细胞凋亡在肝纤维化过程中可能起到的作用,表明ERS是细胞的一种自我保护机制,但是过度的ERS会对细胞造成不可逆的损伤甚至会促使凋亡。但对于ERS介导细胞凋亡在肝纤维化过程中的作用机制还未明确,有待进一步研究。随着对肝细胞疾病与ERS关系研究的不断深入,未来肝脏疾病的治疗将会更加有的放矢。
Abstract:Recent studies have found that endoplasmic reticulum stress( ERS) is a common feature of the pathogenesis of organ fibrosis.However,the functional alteration of ERS and its potential role in the process of liver fibrosis is still unclear. This review summarizes the potential function of ERS and ERS-mediated apoptosis in liver fibrosis,suggesting that ERS is a cellular self-protection mechanism,but excessive ERS could cause irreversible cell damage and even induce apoptosis. However,the mechanism of ERS-mediated apoptosis involved in liver fibrosis has not been well understood and merits further exploration. With the further thorough research on the association between liver diseases and ERS,the treatments for liver diseases will be more apposite in the future.
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Key words:
- liver cirrhosis /
- endoplasmic reticulum stress /
- apoptosis /
- review
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