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Research advances in therapeutic strategies against covalently closed circular DNA of hepatitis B virus
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摘要:
HBV感染常常导致肝硬化和肝癌的发生,在全球范围产生了严重的社会、医疗和经济负担。现有抗HBV药物可以控制病情进展,但无法彻底根除HBV,主要原因是肝细胞核内共价闭合环状DNA(ccc DNA)持续存在。从干扰ccc DNA合成、促进ccc DNA降解、沉默ccc DNA的功能3个方面总结了靶向ccc DNA的治疗策略研究进展。认为靶向ccc DNA是很有前景的治疗方法,有望彻底治愈慢性HBV感染。
Abstract:Chronic infection with hepatitis B virus( HBV) often leads to the development of liver cirrhosis and liver cancer,creating immense sociological,clinical,and economic burdens worldwide. Although current anti-HBV drugs can control the disease progression,they often fail to eliminate the virus because of the presence of covalently closed circular DNA( ccc DNA) in the hepatocyte nucleus. We review the research advances in therapeutic strategies against ccc DNA from the aspects of interfering with ccc DNA synthesis,promoting ccc DNA degradation,and silencing ccc DNA. Targeting ccc DNA is a promising approach that may lead to a cure of chronic HBV infection.
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Key words:
- hepatitis B virus /
- DNA,circular /
- targeted therapy /
- review
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