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Research advances in acute-on-chronic liver failure
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摘要:
慢加急性肝衰竭(ACLF)病死率极高。早期诊断可以减少并发症的发生、提高生存率。归纳了ACLF的概念、病因以及涉及炎症反应、氧活性、代谢等方面的发病机制。总结了ACLF的最新治疗方法和影响预后的因素。认为ACLF发展对患者生命造成巨大威胁,对ACLF应该有一个全球普遍适用的定义,从而进一步指导和规范我国ACLF的临床诊治,而且需要前瞻性研究来确定慢性肝病发展为ACLF的危险因素。
Abstract:Acute-on-chronic liver failure( ACLF) is a severe liver disease with high mortality in China. Early diagnosis could reduce complications and improve the survival rate. In the present review,the definition,etiology,and pathogenesis related to inflammatory response,reactive oxygen species,and metabolism are reviewed. Also,the new approaches to the treatment of ACLF and prognostic factors are summarized. Generally,the development of ACLF is considered to be life-threatening for patients. Therefore,a universal definition of ACLF should be proposed,which would provide good guidance and standard for the clinical diagnosis and treatment of ACLF in China. In addition,the risk factors for ACLF in patients with chronic liver diseases need to be determined by prospective studies.
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Key words:
- liver failure /
- review
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