It is vital for reducing the occurrence of complications,such as liver cirrhosis and hepatic carcinoma,to early diagnose liver fibrosis in chronic hepatitis B and intervene in time with antiviral therapy. Although liver biopsy is the " golden standard" for the diagnosis of fibrosis,it has certain disadvantages,such as complicated operation,invasion,and occurrence of complications. Therefore,non- invasive diagnosis models have gained more and more attention clinically. In this review,we summarizes the non- invasive diagnosis models for chronic hepatitis B that have been established throughout the world. It is noticed that there are a number of models being studied and each model has a diagnostic value,to some degree,but a lack of consensus exists. The development of more efficient models that can replace liver biopsy still needs further research to assess liver fibrosis in chronic hepatitis B and guide antiviral therapy.