Objective To preliminarily investigate the relationship between the chronic hepatitis C virus( HCV) genotypes,2a and 1b,and thyroid hormone levels and autoantibodies. Methods In patients who were admitted to our hospital and diagnosed with chronic hepatitis C from October 2013 to December 2014,reverse transcription- polymerase chain reaction was performed to determine the HCV genotype. A total of 196 patients with HCV genotype 2a or 1b were enrolled as subjects. The levels of thyroid hormone and thyroid autoantibodies were determined by chemiluminescence immunoassay,and the relationship between the HCV genotype and thyroid function was analyzed. Between- group comparison of continuous data was performed by t test,and the risk factors were evaluated by logistic regression analysis. Results In the 196 patients with hepatitis C,57. 7%( n = 113) were infected with HCV- 2a,and 42. 3%( n = 83) were infected with HCV- 1b.There were no significant differences in levels of thyroid hormone and thyroid autoantibodies between patients with HCV- 2a and HCV- 1b( P > 0. 05). In the 92 patients who were treated with interferon,there were no significant differences in levels of thyroid hormone and thyroid autoantibodies between patients with HCV- 2a and HCV- 1b( P > 0. 05). Logistic regression analysis showed that the genotype classification was not a risk factor for abnormal thyroid autoantibodies( OR = 2. 012,P > 0. 05). Conclusion There is no intrinsic link between chronic HCV genotype classification and thyroid function. The genotype classification has no substantial effect on thyroid function.