Objective To compare the efficacy of sodium morrhuate versus lauromacrogol in the treatment of hepatic cyst. Methods Seventy- four patients with hepatic cyst who were admitted to our hospital from January 2009 to May 2013 were enrolled as subjects and divided into two groups. After the cystic fluid was drained by percutaneous liver biopsy,sodium morrhuate solution was injected into the cystic cavity for adhesion and sclerosis in 46 patients in group A,and lauromacrogol solution was injected in 28 patients in group B. The incidence rates of pain in patients during and after surgery were compared between the two groups. The follow- up comparison of hepatic cyst recurrence rates within one year after surgery was performed between the two groups. Between- group comparison was performed by χ2test. Results Five patients( 10. 87%) in group A and two patients( 7. 14%) in group B had recurrence within one year after treatment. There was no significant difference in recurrence rate between the two groups( χ2= 0. 283,P > 0. 05). The incidence of pain in group A was significantly higher than that in group B( χ2= 5. 258,P < 0. 05). Conclusion With the same efficacy as sodium morrhuate in the treatment of hepatic cyst,lauromacrogol can be routinely used as a sclerosing agent due to its mild side effects.